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ElisaMäkäräinen

Obstruction of the Small or Large Bowel, Paralytic Ileus and Pseudo-Obstruction

Essentials

  • Acute mechanical intestinal obstruction should be identified and treated immediately. The treatment of imminent strangulation is particularly urgent (see also Acute abdomen in the adult Acute Abdomen in the Adult).
  • In paralytic ileus, conservative treatment should be started early enough.
  • Treat pseudo-obstruction of the colon by removing air or with neostigmine + glycopyrronium medication.
  • Adhesive small bowel obstruction is common especially in patients with a history of abdominal surgery.
  • Paralysis of the small intestine and colonic pseudo-obstruction are often associated with surgical treatment or other severe disease.
  • It is essential to identify those at risk of intestinal perforation and requiring immediate treatment.

Aetiology

Small bowel obstruction

  • Adhesions resulting from abdominal surgery
  • Incarcerated hernia
  • Partial or complete rotation of the small bowel
  • Stenosis due to Crohn's disease
  • Invagination
  • Constriction or compression due to external causes, such as a tumour or peritoneal carcinosis

Large bowel obstruction

  • Colorectal cancer
  • Volvulus (the bowel twisting on itself)
  • Diverticulosis

Paralysis of the small bowel and colonic pseudo-obstruction

  • Other surgical treatment with resulting paralytic ileus
  • Severe systemic disease (e.g. infection, particularly sepsis; pancreatitis)
  • Severe trauma
  • Drugs, such as opioids
  • Metabolic disorder, such as hypokalaemia

Symptoms and findings

  • Abdominal pain may be constant or fluctuating.
    • Often mild and fluctuating at first, getting more severe and more constant.
  • Vomiting; may be absent
  • There may be bowel movements at first as the distal bowel empties but typically there are no bowel movements and no passing of air.
  • If pain is not relieved by a functional nasogastric tube, intestinal ischaemia should be suspected.
    • The purpose of inserting a nasogastric tube is to alleviate nausea and vomiting and relieve intestinal distension to alleviate pain and to promote bowel movement.
  • Any incarcerated hernia must be reduced without delay (see also Hernias in Adults).

Investigations

  • Vital signs (blood pressure, heart rate, oxygen saturation, body temperature)
  • Laboratory tests to check the patient's general condition
    • Basic blood count, CRP, sodium, potassium, creatinine, ALT, ALP, pancreas-specific plasma amylase, blood glucose, chemical screening of urine + bacterial culture of urine
    • To exclude symptoms of cardiac origin, ECG, TnT/TnI
  • Abdominal CT is a basic investigation in patients with intestinal obstruction; further treatment should be chosen based on the findings and the patient's general condition.
    • CT will show the level and completeness of obstruction and often also the aetiology if it is other than an adhesion from preceding surgery.
  • Small bowel follow-through examination, where the patient drinks a water-soluble contrast medium or is given this through a nasogastric tube, may trigger bowel movement. Entry of the contrast medium into the large bowel predicts successful conservative treatment.

Treatment

  • If intestinal obstruction or ileus is suspected, the patient should be evaluated at an emergency unit with facilities for CT and, when necessary, for surgical treatment.
    • Gastrosurgical assessment or consultation is often necessary.
  • Patients with a history of constipation can be treated at a primary health care unit or on an outpatient basis if they are pain-free and in good general condition.
  • The urgency of treatment depends on the patient's general condition and imaging findings.
    • If a patient with small bowel obstruction becomes pain-free with the insertion of a nasogastric tube, conservative treatment can usually be tried at first. If the patient is in pain, strangulation should be suspected and further treatment arranged without delay.
    • In the case of large bowel obstruction, distended caecum and pain indicate a need for further measures.

Treatment of intestinal obstruction depending on aetiology

DiseaseFirst-line treatmentOther treatment
Small bowel obstruction and paralytic ileusAnalgesics
Fluid administration
Nasogastric tube
Consider administering a water-soluble contrast medium through a nasogastric tube.
Obstruction caused by a tumour in the large bowelProximal stoma or excision of the tumour in the large bowel, depending on local practice and available resourcesPlacement of a stent at the obstruction can also be considered in selected patients.
Sigmoid volvulusRelease of bowel pressure (deflation) by inserting a rectal tube or by endoscopyDepending on the patient's circumstances, consider sigmoid resection during the period of treatment on the hospital ward or urgently.
Volvulus of the caecumRight hemicolectomy
Colonic pseudo-obstructionWithdrawal of medication causing paralytic ileus
Mobilization as far as possible
Bowel deflation
Consider neostigmine and glycopyrronium, unless contraindicated.

    References

    • Wilkie BD, Noori J, Johnston M, et al. Pyridostigmine in chronic intestinal pseudo-obstruction - a systematic review. ANZ J Surg 2023;93(9):2086-2091 [PubMed]
    • Ten Broek RPG, Krielen P, Di Saverio S, et al. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group. World J Emerg Surg 2018;13():24 [PubMed]