Leucocytopenia - Related Resources

Cochrane reviews

Liposomal amphotericin B appears to be significantly more effective than voriconazole for empirical therapy of suspected fungal infections in neutropenic cancer patients Voriconazole Versus Amphotericin B in Cancer Patients with Neutropenia.
Antibiotic prophylaxis reduces all-cause mortality in afebrile neutropenic patients following chemotherapy. The evidence is strongest for quinolones. The addition of gram-positive prophylaxis reduces the incidence of gram-positive bacteraemia Antibiotic Prophylaxis for Neutropenic Patients.
Oral antibiotics are an acceptable alternative to intravenous antibiotics for treating febrile neutropenia in cancer patients at low risk for complications Oral Versus Intravenous Antibiotic Treatment for Febrile Neutropenia in Cancer Patients.
Evidence is inconclusive to support or refute generalised use of granulocyte transfusions to treat infections in patients with neutropenia caused by chemotherapy Granulocyte Transfusions for Treating Infections in Neutropenic Patients.
Empirical anti-Gram-positive antibiotic treatment with glycopeptides (vancomycin, teicoplanin) appears not to improve outcomes in febrile neutropenic cancer patients Empirical Anti-Gram-Positive Antibiotic Treatment for Febrile Neutropenic Cancer Patients.

Imipenem-cilastatin may be more effective than beta-lactam based regimens for empirically treating febrile neutropenic patients Imipenem-Cilastatin for Febrile Neutropenic Patients.

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