Pharmacological Treatment of Depression - Related Resources
Cochrane reviews
- For men with antidepressant-induced erectile dysfunction, the addition of sildenafil appears to be an effective strategy Managing Sexual Dysfunction Induced by Antidepressant Medication.
- There appear to be differences in efficacy and tolerability between fluoxetine and certain other antidepressants, but the clinical meaning of these differences is uncertainFluoxetine Versus other Types of Pharmacotherapy for Depression.
- Antiglucocorticoids might possibly be beneficial in the treatment of mood disorders, but the evidence is insufficient.Antiglucocorticoid Treatments for Mood Disorders.
- Escitalopram may be more efficacious than citalopram but not other antidepressants for achieving acute phase response and remission (6-12 weeks) in the treatment of major depression Escitalopram Versus other Antidepressive Agents for Acute Depression.
- In major depression quetiapine appears to be more effective than placebo. Aripiprazole, quetiapine and partly also olanzapine and risperidone augmentation, when added on antidepressants, also appears to be beneficial. In dysthymia, amisulpride appears to be beneficial. Most SGAs appears to have worse tolerability Second-Generation Antipsychotics for Major Depression and Dysthymia.
- More depressive patients appear to respond to sertraline than fluoxetine but there is no difference between sertraline and other antidepressants Sertraline Versus other Antidepressive Agents for Depression.
- Citalopram appears to be more efficacious than paroxetine and reboxetine and more acceptable than tricyclics, reboxetine and venlafaxine, but it appears to be less efficacious than escitalopram in major depression Citalopram for Depression.
- Alprazolam may reduce depressive symptoms more effectively than placebo and as effectively as tricyclic antidepressants Alprazolam for Depression.
- Duloxetine does not appear to provide an advantage in efficacy over other antidepressive agents for the acute-phase treatment of major depression. In terms of acceptability and tolerability duloxetine appears to be worse than escitalopram and venlafaxine Duloxetine Versus other Anti-Depressive Agents for Depression.
- In the acute phase of depression, paroxetine may be less effective than citalopram at 6 to 12 weeks or mirtazapine at 1 to 4 weeks. However, paroxetine may be better than reboxetine at 1 to 4 weeks. There is probably no difference between paroxetine and other antidepressants at increasing response to treatment at any time point Paroxetine Versus other Anti-Depressive Agents for Depression.
Literature
- Qaseem A, Snow V, Denberg TD, Forciea MA, Owens DK, Clinical Efficacy Assessment Subcommittee of American College of Physicians. Using second-generation antidepressants to treat depressive disorders: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2008 Nov 18;149(10):725-33. [PubMed]
- Gartlehner G, Gaynes BN, Hansen RA, Thieda P, DeVeaugh-Geiss A, Krebs EE, Moore CG, Morgan L, Lohr KN. Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians. Ann Intern Med 2008 Nov 18;149(10):734-50. [PubMed]
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