Contraindicated in:
Use Cautiously in:
Derm: ERYTHEMA MULTIFORME, photosensitivity, exfoliative dermatitis, rash.
Endo: hypoglycemia.
F and E: hyponatremia.
GI: constipation, cramps, diarrhea, drug-induced hepatitis, dyspepsia, ↑ appetite, nausea, vomiting.
Hemat: APLASTIC ANEMIA, agranulocytosis, hemolytic anemia, leukopenia, pancytopenia, thrombocytopenia.
Metab: ↑weight.
Neuro: dizziness, drowsiness, headache, weakness.
Drug-Drug:
(Generic available)
Absorption: Well absorbed following oral administration; micronized forms have better absorption.
Distribution: Reaches high concentrations in bile and crosses the placenta.
Metabolism/Excretion: Mostly metabolized by the liver (primarily by CYP2C9).
Half-life: 10 hr.