Contraindicated in:
Use Cautiously in:
CV: peripheral edema, chest pain, hypotension.
Derm: pruritus, rash, STEVENS-JOHNSON SYNDROME.
F and E: hypokalemia, hypomagnesemia.
GI: ↑ liver enzymes, constipation, diarrhea, nausea, vomiting, ↓ appetite, dyspepsia.
GU: renal failure.
Local: injection site reactions.
MS: back pain.
Neuro: fatigue, headache, insomnia, anxiety, delirium.
Resp: cough, dyspnea, respiratory failure.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS , infusion-related reactions.
Drug-Drug:
Drug-Natural Products:
Spectrum:
Absorption: Prodrug is rapidly converted to isavuconazole, the active component. 98% absorbed following oral administration. Similar conversion follows intravenous administration, resulting in complete bioavailability.
Distribution: Extensively distributed.
Protein Binding: >99%.
Metabolism/Excretion: Extensively metabolized (mostly by CYP3A4 and CYP3A5); inactive metabolites are mostly renally eliminated, <1% excreted unchanged in urine.
Half-life: 130 hr.