Contraindicated in:
Use Cautiously in:
Reflects combined therapy with corticosteroids and cyclosporine
CV: edema, hypotension, pericardial effusion.
Derm: acne, rash, thrombocytopenic purpura.
F and E: hypokalemia.
Endo: hyperglycemia.
GI: ascites, hepatotoxicity.
GU: amenorrhea, infertility (males), menorrhagia, ovarian cysts, renal impairment.
Hemat: leukopenia, thrombocytopenia, anemia.
Metab: hypercholesterolemia, hypertriglyceridemia.
MS: arthralgias.
Neuro: tremor , PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML), insomnia.
Resp: interstitial lung disease, pulmonary hypertension.
Misc: ANGIOEDEMA, (INCLUDING ACTIVATION OF LATENT VIRAL INFECTIONS SUCH AS BK VIRUS-ASSOCIATED NEPHROPATHY AND CLOSTRIDIOIDES DIFFICILEINFECTION -ASSOCIATED DIARRHEA [CDAD]), ↓ wound healing, lymphocele, lymphoma.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Kidney Transplantation
Hepatic Impairment
Lymphangioleiomyomatosis
Hepatic Impairment
Absorption: Rapidly absorbed following oral administration (14% bioavailability).
Distribution: Concentrates in erythrocytes; distributes to heart, intestines, kidneys, liver, lungs, muscle, spleen, and testes in high concentrations.
Protein Binding: 92%.
Metabolism/Excretion: Extensively metabolized (some metabolism by P450 3A4 system); 91% excreted in feces.
Half-life: 62 hr.