Contraindicated in:
Use Cautiously in:
Drug-Drug:
Drug-Food:
Renal Impairment
Absorption: Well absorbed (>90%) following oral administration.
Distribution: Widely distributed to tissues.
Metabolism/Excretion: Primarily metabolized in the liver via the CYP3A4 isoenzyme; 80% excreted by kidneys via cationic renal secretion, mostly as unchanged drug; 20% excreted as inactive metabolites.
Half-life: 10 hr.
(plasma concentrations)
ROUTE | ONSET | PEAK | DURATION |
PO | within hrs | 23 hr | 1224 hr |
Steady state levels are achieved after 23 days.