Unlabeled Uses:
Contraindicated in:
Use Cautiously in:
CV: hypotension, MYOCARDIAL FIBROSIS.
Derm: alopecia.
Endo: gonadal suppression, syndrome of inappropriate antidiuretic hormone (SIADH).
GI: anorexia, nausea, vomiting.
GU: hematuria, ↓ fertility, HEMORRHAGIC CYSTITIS.
Hemat: thrombocytopenia, anemia, LEUKOPENIA.
Metab: hyperuricemia.
Resp: PULMONARY FIBROSIS.
Misc: SECONDARY MALIGNANCY.
Drug-Drug:
(Generic available)
Therapeutic Classification: antineoplastics, Immunosuppressant agents
Pharmacologic Classification: alkylating agents
Absorption: Inactive parent drug is well absorbed from the GI tract. IV administration results in complete bioavailability.
Distribution: Widely distributed. Limited penetration of the blood-brain barrier.
Metabolism/Excretion: Converted to active drug by the liver; 30% eliminated unchanged by the kidneys.
Half-life: 46.5 hr.