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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

CV: hypotension, chest pain, edema

Derm: rash

GI: abdominal pain, diarrhea, nausea, vomiting

GU: erectile dysfunction, impaired renal function

F and E: hyperkalemia

MS: muscle cramps

Neuro: dizziness, fatigue, headache, insomnia, weakness

Resp: cough, dyspnea

Misc: ANGIOEDEMA

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Hypertension

Heart Failure

US Brand Names

Monopril

Action

  • Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also plasma renin levels and aldosterone levels. Net result is systemic vasodilation.
Therapeutic effects:
  • Lowering of BP in patients with hypertension.
  • Decreased afterload and symptoms in patients with heart failure.

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: ace inhibitors

Pharmacokinetics

Absorption: 36% absorbed following oral administration.

Distribution: Minimally distributed to tissues.

Protein Binding: 99.4%.

Metabolism/Excretion: Converted by the liver and GI mucosa to fosinoprilat, the active metabolite: 50% excreted in urine, 50% in feces.

Half-Life: 12 hr.

Time/Action Profile

(effect on BP—single dose)
ROUTEONSETPEAKDURATION
POWithin 1 hr2–6 hr24 hr

Full effects may not be noted for several wk.



Patient/Family Teaching

Pronunciation

foe-SIN-oh-pril