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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

CV: hypotension

Derm: rash

F and E: hyperkalemia

GI: diarrhea, dyspepsia

GU: renal impairment

MS: back pain

Neuro: dizziness, headache, weakness

Resp: cough

Misc: ANGIOEDEMA

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Hypertension

Stable Coronary Artery Disease

Renal Impairment

US Brand Names

Aceon

Action

  • Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also increase plasma renin levels and reduce aldosterone levels. Net result is systemic vasodilation.
Therapeutic effects:
  • Lowering of BP in patients with hypertension.
  • Decreased risk of death from cardiovascular causes or MI in patients with stable coronary artery disease.

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: ace inhibitors

Pharmacokinetics

Absorption: 25% bioavailability as perindoprilat following oral administration.

Distribution: Unknown.

Metabolism/Excretion: Converted by the liver to perindoprilat, the active metabolite; primarily excreted in urine.

Half-Life: Perindoprilat: 3–10 hr ( in renal impairment).

Canadian Brand Names

Coversyl

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POwithin 1–2 hr3–7 hrup to 24 hr



Patient/Family Teaching

Pronunciation

per-IN-do-pril