section name header

Indications

BEERS REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: chest pain, peripheral edema.

Derm: rash.

GI: dry mouth, unpleasant taste.

Neuro: abnormal thinking, behavior changes, COMPLEX SLEEP BEHAVIORS (INCLUDING SLEEP DRIVING, SLEEP WALKING, OR ENGAGING IN OTHER ACTIVITIES WHILE SLEEPING), depression, hallucinations, headache, next day impairment.

Interactions

Drug-Drug:

Availability

(Generic available)

Route/Dosage

Hepatic Impairment

US Brand Names

Lunesta

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: sedative/hypnotics

Pharmacologic Classification: cyclopyrrolones

Pharmacokinetics

Absorption: Rapidly absorbed after oral administration.

Distribution: Unknown.

Metabolism/Excretion: Extensively metabolized by the liver by the CYP3A4 and CYP2E1 isoenzymes; metabolites are renally excreted, <10% excreted unchanged in urine.

Half-life: 6 hr.

Contr. Subst. Schedule

Schedule IV (C-IV)

Time/Action Profile

(plasma concentrations)

ROUTEONSETPEAKDURATION
POrapid1 hr6 hr

Patient/Family Teaching

Pronunciation

es-ZOP-i-klone