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Indications

REMS

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: CARDIAC ARREST, QT interval prolongation, syncope, TORSADES DE POINTES, VENTRICULAR ARRHYTHMIAS.

GI: constipation, abdominal pain/distention/discomfort, dry mouth, nausea, vomiting.

Neuro: drowsiness, dizziness.
Misc: (INCLUDING ANAPHYLAXIS)HYPERSENSITIVITY REACTIONS .

Interactions

Drug-Drug:

Drug-Natural Products:

Availability

(Generic available)

Route/Dosage

Acute Diarrhea

Chronic Diarrhea

Reduction of Ileostomy Output

US Brand Names

Imodium A-D

Action

Therapeutic Effects:

Classifications

Therapeutic Classification: antidiarrheals

Pharmacokinetics

Absorption: Not well absorbed following oral administration.

Distribution: Does not cross the blood-brain barrier.

Protein Binding: 97%.

Metabolism/Excretion: Metabolized partially by the liver, undergoes enterohepatic recirculation; 30% eliminated in the feces. Minimal excretion in the urine.

Half-life: 10.8 hr.

Time/Action Profile

(relief of diarrhea)

ROUTEONSETPEAKDURATION
PO1 hr2.5–5 hr10 hr

Patient/Family Teaching

Pronunciation

loe-PER-a-mide