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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: bradycardia, hypotension

GI: nausea, vomiting

Hemat: activated partial thromboplastin time (aPTT), prothrombin time (PT)/international normalized ratio (INR)

Neuro: headache

Misc: anaphylaxis

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Routine Reversal of Rocuronium- or Vecuronium-Induced Blockade

Immediate Reversal of Rocuronium-Induced Blockade

US Brand Names

Bridion

Action

  • Forms a complex with rocuronium or vecuronium, reducing the amount of the neuromuscular blocker available to bind to nicotinic cholinergic receptors in the neuromuscular junction.
Therapeutic effects:
  • Reversal of neuromuscular blocking effects.

Classifications

Therapeutic Classification: antidotes

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.

Distribution: Well distributed.

Metabolism/Excretion: Primarily excreted unchanged in urine (95%); <1% excreted in feces.

Half-Life: 2 hr ( in renal impairment).

Time/Action Profile

(reversal of neuromuscular blocking effects)

ROUTEONSETPEAKDURATION
IVunknown2–5 minunknown



Patient/Family Teaching

Pronunciation

soo-GAM-ma-dex