- Following sugammadex use, wait 24 hr before readministering rocuronium or vecuronium. If more immediate neuromuscular blockade is needed, a nonsteroidal neuromuscular-blocking agent (e.g., succinylcholine) may be required.
Routine Reversal of Rocuronium- or Vecuronium-Induced Blockade
- IV (Adults and Children 2<17 yr): Deep block (if spontaneous recovery of twitch response has reached 1 to 2 post-tetanic counts and there are no twitch responses to train-of-four [TOF] stimulation): 4 mg/kg (actual body weight) as a single dose; Moderate block (if spontaneous recovery has reached the reappearance of the 2nd twitch [T2] in response to TOF stimulation): 2 mg/kg (actual body weight) as a single dose.
Immediate Reversal of Rocuronium-Induced Blockade
- IV (Adults ): 16 mg/kg (actual body weight) as a single dose administered soon (3 minutes) after administration of a single dose of 1.2 mg/kg of rocuronium.
Therapeutic Classification: antidotes
Absorption: IV administration results in complete bioavailability.
Distribution: Well distributed.
Metabolism/Excretion: Primarily excreted unchanged in urine (95%); <1% excreted in feces.
Half-Life: 2 hr (↑ in renal impairment).
(reversal of neuromuscular blocking effects)
ROUTE | ONSET | PEAK | DURATION |
---|
IV | unknown | 25 min | unknown |