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Indications

REMS


Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Exercise Extreme Caution in:

Adv. Reactions/Side Effects

CV: hypotension, chest pain

Derm: rash

F and E: hyperkalemia

GI: abdominal pain, diarrhea, nausea, vomiting

GU: erectile dysfunction, renal impairment

Neuro: dizziness, fatigue, headache, weakness

Resp: cough

Misc: ANGIOEDEMA

Interactions

Drug-drug:

Availability

(Generic available)

Route/Dosage

Hypertension

Renal Impairment

Renal Impairment

Heart Failure

Renal Impairment

Acute Myocardial Infarction

Renal Impairment

US Brand Names

Prinivil, Qbrelis, Zestril

Action

  • Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also plasma renin levels and aldosterone levels. Net result is systemic vasodilation.
Therapeutic effects:
  • Lowering of BP in hypertensive patients.
  • Increased survival and decreased symptoms in patients with HF.
  • Increased survival after MI.

Classifications

Therapeutic Classification: antihypertensives

Pharmacologic Classification: ace inhibitors

Pharmacokinetics

Absorption: 25% absorbed following oral administration (much inter-individual variability).

Distribution: Crosses the placenta; may enter breast milk.

Metabolism/Excretion: 100% eliminated by the kidneys.

Half-Life: 12 hr ( in renal impairment).

Time/Action Profile

(effect on BP-single dose)
ROUTEONSETPEAKDURATION
PO1 hr6 hr24 hr

Full effects may not be noted for several weeks.



Patient/Family Teaching

Pronunciation

lyse-IN-oh-pril

Pill Image

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