• Premenstrual dysphoric disorder (PMDD)
• Depression.
• Smoking cessation.
• Insomnia.

Contraindicated in:

• Hypersensitivity.
• Pregnancy and lactation.

Use Cautiously in:

• Eosinophilia.
• Kidney disease.
• Liver disease.

EENT: visual blurring.

GI: abdominal pain, dry mouth, heartburn, nausea.

Hemat: eosinophilia-myalgia syndrome.

Neuro: ataxia, drowsiness, headache, lightheadedness.

Natural-Drug Products:

• Increased risk of serotonergic effects and serotonin syndrome with SSRIs, dextromethorphan, meperidine, tricyclic antidepressants, monoamine oxidase inhibitors, and tramadol.
• Increased sedation with CNS depressants.

Natural-Natural Products:

• Additive sedation with herbs or supplements that have sedative properties such as kavaSt. John's wortvalerian5–HTPand others.
• Increased risk of serotonin syndrome with St. John's wort..

• Capsules: Tablets: 500 mg;

• PO (Adults): Insomnia: 1 gram 20 minutes before bedtime; Depression: 300 mg/day; Prementrual syndrome: 6 grams/day; Smoking cessation: 50 mg/kg/day.

tryptophan

• L-tryptophan is an essential amino acid that is converted by the body to 5–hydroxytryptophan (5–HTP) and then to serotonin. Both L-tryptophan and 5–HTP cross the blood-brain barrier and have sedative effects. Depletion of endogenous tryptophan can cause a relapse in depression symptoms.

• Improved symptoms of depression.
• Improved sleep.

Therapeutic Classification: sedative/hypnotics, antidepressants

Absorption: Unknown.

Distribution: Unknown.

Metabolism/Excretion: Unknown.

Half-life: Unknown.

• Instruct patient to take as directed; do not take more than directed.
• Advise patient to notify health care professional of symptoms of esosinophilia-myalgia sydrome occur.
• Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

EL TRIP-tuh-fan