trandolapril

Contraindicated in:

Hypersensitivity;
History of angioedema with previous use of ACE inhibitors;
Concurrent use with aliskiren in patients with diabetes or moderate to severe renal impairment (CCr <60 mL/min);
Concurrent use with sacubitril/valsartan; must be a 36-hr washout period after switching to/from sacubitril/valsartan;
OB: Pregnancy;
Lactation: Lactation.

Use Cautiously in:

Black patients (monotherapy for hypertension less effective, may require additional therapy; higher risk of angioedema);
Surgery/anesthesia (hypotension may be exaggerated);
Renal impairment, hypovolemia, hyponatremia, and concurrent diuretic therapy (initial dose ↓ recommended);
Rep: Women of reproductive potential;
Pedi: Safety and effectiveness not established in children;
Geri: Initial dose ↓ recommended in older adults.

Exercise Extreme Caution in:

Family history of angioedema.

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

Derm: rash

F and E: hyperkalemia, hypocalcemia

GI: diarrhea, dyspepsia

GU: renal impairment

Metab: hyperuricemia

MS: myalgia

Neuro: weakness

Resp: cough

Misc: ANGIOEDEMA

Interactions ⬆ ⬇

Drug-drug:

Concurrent use with sacubitril↑ risk of angioedema; concurrent use contraindicated; do not administer within 36 hr of switching to/from sacubitril/valsartan.
Aliskiren↑ risk of hyperkalemia, renal dysfunction, hypotension, and syncope; concurrent use contraindicated in patients with diabetes or CCr <60 mL/min.
Excessive hypotension may occur with concurrent use of diuretics.
Additive hypotension with other antihypertensive agents.
↑risk of hyperkalemia with concurrent use of potassium supplements, potassium-containing salt substitutes, and potassium-sparing diuretics.
Angiotensin II receptor blockers↑ risk of hyperkalemia, renal dysfunction, hypotension, and syncope; avoid concurrent use.
NSAIDs and selective COX-2 inhibitors may blunt the antihypertensive effect and ↑ the risk of renal dysfunction.
↑levels and may ↑ the risk of lithium toxicity.
↑risk of angioedema with temsirolimus, sirolimus, or everolimus.

Availability ⬆ ⬇

(Generic available)

Tablets: 0.5 mg; 1 mg; 2 mg; 4 mg
In combination with: verapamil. See Appendix [not included in this PDA edition].

Route/Dosage ⬆ ⬇

Hypertension

PO (Adults ): 1 mg once daily (2 mg in Black patients). May be ↑ weekly up to 4 mg once daily; twice-daily dosing may be necessary in some patients (initiate therapy with 0.5 mg/day in patients receiving diuretics).

Renal Impairment

PO (Adults ): CCr <30 mL/min: Initiate therapy at 0.5 mg once daily; may be slowly titrated upward (max dose = 4 mg/day).

Hepatic Impairment

PO (Adults ): Initiate therapy at 0.5 mg once daily; may be slowly titrated upward (max dose = 4 mg/day).

Heart Failure Post-MI or Left Ventricular Dysfunction Post-MI

PO (Adults ): 1 mg once daily; titrate up to 4 mg once daily if possible.

Renal Impairment

PO (Adults ): CCr <30 mL/min: Initiate therapy at 0.5 mg once daily; may be slowly titrated upward (max dose = 4 mg/day).

Hepatic Impairment

PO (Adults ): Initiate therapy at 0.5 mg once daily; may be slowly titrated upward (max dose = 4 mg/day).

Action ⬆ ⬇

Angiotensin-converting enzyme (ACE) inhibitors block the conversion of angiotensin I to the vasoconstrictor angiotensin II. ACE inhibitors also prevent the degradation of bradykinin and other vasodilatory prostaglandins. ACE inhibitors also ↑ plasma renin levels and ↓ aldosterone levels. Net result is systemic vasodilation.

Therapeutic effects:

Lowering of BP in patients with hypertension.
Increased survival after MI.

Classifications ⬆ ⬇

Therapeutic Classification: antihypertensives

Pharmacologic Classification: ace inhibitors

Pharmacokinetics ⬆ ⬇

Absorption: 70% absorbed following oral administration.

Distribution: Crosses the placenta; enters breast milk.

Metabolism/Excretion: Converted by the liver to trandolaprilat, the active metabolite; 33% excreted in urine, 66% in feces.

Half-Life: Trandolapril: 6 hr; Trandolaprilat: 22.5 hr (↑ in renal impairment).

Canadian Brand Names ⬆ ⬇

Time/Action Profile ⬆ ⬇

(antihypertensive effect)

ROUTE	ONSET	PEAK	DURATION
PO	within 1–2 hr*	within 1 wk‡	up to 24 hr‡

*After single dose.

‡Chronic dosing.

Patient/Family Teaching ⬆ ⬇

Emphasize importance of continuing to take medication as directed at the same time each day, even if feeling well. Take missed doses as soon as remembered but not if almost time for next dose. Do not double doses. Warn patient not to discontinue ACE inhibitor therapy unless directed by health care professional.
- Caution patient to avoid salt substitutes containing potassium or foods containing high levels of potassium or sodium unless directed by health care professional. See Food Sources for Specific Nutrients.
- Caution patient to change positions slowly to minimize orthostatic hypotension. Use of alcohol, standing for long periods, exercising, and hot weather may increase orthostatic hypotension.
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications, especially NSAIDs and cough, cold, or allergy remedies.
- May cause dizziness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
- Advise patient to inform health care professional of medication regimen prior to treatment or surgery.
- Instruct patient to notify health care professional immediately if rash; mouth sores; sore throat; fever; swelling of hands or feet; irregular heartbeat; chest pain; dry cough; hoarseness; swelling of face, eyes, lips, or tongue; or difficulty swallowing or breathing occurs. Persistent dry cough may occur and may not subside until medication is discontinued. Consult health care professional if cough becomes bothersome. Also notify health care professional if nausea, vomiting, or diarrhea occurs and continues.
- Advise diabetic patients to monitor blood glucose closely, especially during first mo of therapy; may cause hypoglycemia.
- Advise females of reproductive potential to use contraception and notify health care professional if pregnancy is planned or suspected and to avoid breastfeeding during therapy. If pregnancy is detected, discontinue medication as soon as possible.
- Emphasize the importance of follow-up examinations to monitor effectiveness of medication.
Hypertension: Encourage patient to comply with additional interventions for hypertension (weight reduction, low-sodium diet, discontinuation of smoking, moderation of alcohol consumption, regular exercise, and stress management). Medication controls but does not cure hypertension.
- Instruct patient and family on correct technique for monitoring BP. Advise them to check BP at least weekly and to report significant changes to health care professional.

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Indications ⬇

Contraind./Precautions ⬆ ⬇