1.CL is a 58-year-old woman recently diagnosed with metastatic non-small cell adenocarcinoma of the lung. The chemotherapy plan, per her oncologist, is to treat with four to six cycles of cisplatin, pemetrexed, and pembrolizumab. Which of the following medication is recommended for the prevention of toxicity during pemetrexed therapy to prevent cytopenias?
A. A monthly B12 injection and daily low-dose folic acid supplementation
B. Urine alkalization until pemetrexed levels have been cleared
C. Leucovorin administered for 48 hours after each dose of pemetrexed
D. Injection of G-CSF