2.BH is an 18-year-old man presenting with pain and swelling in his right leg that he noted after playing paintball. An x-ray of the affected leg showed a concerning lesion requiring further testing. Additional tests (bone scan, MRI, and biopsy of the lesion) confirmed nonmetastatic osteosarcoma in the right proximal tibia. The patient was started on a stand ard regimen of cisplatin, doxorubicin, and high-dose methotrexate. Past medical history includes depression, headaches, ADHD, and seasonal allergies. BH has no known drug allergies. Which of BH’s home medications should be discontinued before he receives high-dose methotrexate?

A. Escitalopram 20 mg PO daily

B. Ibuprofen 400 mg PO BID PRN headaches

C. Methylphenidate 10 mg BID in the morning and afternoon

D. Loratadine 20 mg PO daily