DDx ⬇
- Peptic ulcer disease, gastritis, nonulcer dyspepsia, or cholelithiasis
- Angina pectoris
- Infectious esophagitis: Candida, herpes simplex virus, cytomegalovirus
- Pill-induced esophagitis
- Esophageal motility disorders, eg, achalasia, esophageal spasm, scleroderma
- Radiation esophagitis
- Zollinger-Ellison syndrome (gastrinoma)
Related DDx ⬆ ⬇
Etiology ⬆
- Relaxation or incompetence of lower esophageal sphincter
- Hiatal hernia
- Abnormal acid clearance (esophageal peristalsis), eg, scleroderma
- Impaired salivation (exacerbates gastroesophageal reflux disease), eg, Sjögren’s syndrome, anticholinergics, radiation
- Delayed gastric emptying (exacerbates gastroesophageal reflux disease), eg, gastroparesis