• Hypotension due to other causes, e.g., medications
• Hyperkalemia due to other causes, e.g., renal failure
• Gastroenteritis
• Occult cancer
• Anorexia nervosa
• Hyperpigmentation due to other causes, e.g., hemochromatosis

• Hypotension or shock
• Hyperkalemia
• Weakness
• Fatigue
• Hyponatremia
• Abdominal pain
• Hyperpigmentation
• Chronic diarrhea
• Acute adrenal insufficiency

Primary adrenal insufficiency (Addison's disease)

• Autoimmune
• Surgical removal or trauma
• Infection, e.g., tuberculosis, histoplasmosis
• Adrenal hemorrhage
• Metastatic cancer
• Adrenoleukodystrophy
• Hemochromatosis or amyloidosis
• Congenital adrenal hyperplasia

Secondary adrenal insufficiency

• Pituitary failure (atrophy, necrosis, tumor)
• Exogenous steroids