Related DDx ⬇
Reference
- Modified from Rodnan GP: Postgrad Med.1975;58:6-14. PMID 170600
Etiology ⬆
Primary hyperuricemia
- Increased production of purine
- Idiopathic
- Specific enzyme defects (eg, Lesch-Nyhan syndrome, glycogen storage diseases)
- Decreased renal clearance of uric acid (idiopathic)
Secondary hyperuricemia
- Increased purine catabolism and turnover
- Myeloproliferative disorders
- Lymphoproliferative disorders
- Carcinoma and sarcoma (disseminated)
- Chronic hemolytic anemias
- Cytotoxic drugs
- Psoriasis
- Decreased renal clearance of uric acid
- Intrinsic kidney disease
- Functional impairment of tubular transport:
- Drug-induced (eg, thiazides, probenecid)
- Hyperlacticacidemia (eg, lactic acidosis, alcoholism)
- Hyperketoacidemia (eg, diabetic ketoacidosis, starvation)
- Diabetes insipidus (vasopressin-resistant)
- Bartter's syndrome