(Legend)

Generic Name

• Eszopiclone
  T½ = 6 h
  Protein binding = weakly bound
  Schedule IV
  Pregnancy category C

Trade Name

• Lunesta

Dose Range/Adult Daily Dose

• Range: 1–3 mg po
  Start at 2 mg po hs, may ↑ to 3 mg if needed

Use/Common Side Effects (CSE)

• Use: Insomnia: Sleep latency/maintenance
  CSE: Anxiety, confusion, depression, headache, migraine, dizziness, hallucinations, next day impairment, sleep driving.

Geriatric & Dose Considerations

• Elderly should start with 1 mg po dose and take immediately before bedtime; should not exceed 2 mg/hs

Classification

• Sedative/hypnotic

Assessment Cautions

• Severe hepatic impairment: Start 1 mg. Caution: Concomitant illness, drug/ETOH abuse, psychiatric illness, abrupt withdrawal (see FDA warning)