LOE-va-sta-tin 
Absorption: Poorly and variably absorbed after oral administration.
Distribution: Crosses the blood-brain barrier and placenta.
Metabolism/Excretion: Extensively metabolized by the liver, most during first pass; excreted in bile and feces. 10% excreted unchanged by the kidneys.
Half-life: 3 hr.
Contraindicated in:
Use Cautiously in:
CNS: amnesia, confusion, dizziness, headache, insomnia, memory loss, weakness.
EENT: blurred vision.
GI: abdominal cramps, constipation, diarrhea, flatus, heartburn, altered taste, drug-induced hepatitis, dyspepsia, ↑ liver enzymes, nausea, pancreatitis.
Endo: hyperglycemia.
GU: erectile dysfunction.
Derm: rashes, pruritus.
MS: RHABDOMYOLYSIS, arthralgia, immune-mediated necrotizing myopathy, myopathy, myositis.
Misc: hypersensitivity reactions.
Drug-Drug:
Drug-Natural Products:
Drug-Food:
Renal Impairment
Altoprev, Mevacor
Therapeutic Classification: lipid-lowering agents
Pharmacologic Classification: hmg coa reductase inhibitors (statin)
NDC Code*
