WAR-fa-rin

• Prophylaxis and treatment of:
  • Venous thrombosis,
  • Pulmonary embolism,
  • Atrial fibrillation with embolization.
• Management of myocardial infarction:
  • Decreases risk of death,
  • Decreases risk of subsequent MI,
  • Decreases risk of future thromboembolic events.
• Prevention of thrombus formation and embolization after prosthetic valve placement.

• Interferes with hepatic synthesis of vitamin K-dependent clotting factors (II, VII, IX, and X).

• Prevention of thromboembolic events.

Absorption: Well absorbed from the GI tract after oral administration.

Distribution: Crosses the placenta but does not enter breast milk.

Protein Binding: 99%.

Metabolism/Excretion: Primarily metabolized by the liver via the CYP2C9 isoenzyme, with some metabolism via the CYP3A4 isoenzyme; the CYP2C9 isoenzyme exhibits genetic polymorphism (intermediate or poor metabolizers may have significantly ↑ (S)-warfarin concentrations and an ↑ risk of adverse reactions)..

Half-life: 42 hr.

Contraindicated in:

• Uncontrolled bleeding
• Open wounds
• Active ulcer disease
• Recent brain, eye, or spinal cord injury or surgery
• Severe liver or kidney disease
• Uncontrolled hypertension
• OB: Pregnancy (may cause fetal harm).

Use Cautiously in:

• Malignancy
• Patients with history of ulcer, liver disease, or acute kidney injury
• History of poor compliance
• Asian patients or those who carry the CYP2C9*2 allele and/or the CYP2C9*3 allele, or with the VKORC1 AA genotype (↑ risk of bleeding with standard dosing; lower initial doses should be considered)
• Rep: Women of reproductive potential
• Pedi: Has been used safely in children, but may require more frequent PT/INR assessments.
• Geri: Due to greater than expected anticoagulant response, initiate and maintain at lower doses in older adults.

Derm: dermal necrosis.

GI: cramps, nausea.

GU: CALCIPHYLAXIS.

Hemat: BLEEDING.

Misc: fever.

Drug-Drug:

• Androgens, capecitabine, cefotetan, chloramphenicol, clopidogrel, disulfiram, fluconazole, fluoroquinolones, itraconazole, metronidazole (including vaginal use), thrombolytics, eptifibatide, tirofiban, sulfonamides, quinidine, quinine, NSAIDs, valproates, and aspirin may ↑ the response to warfarin and ↑ the risk of bleeding.
• Chronic use of acetaminophen may ↑ the risk of bleeding.
• Chronic alcohol ingestion may ↓ action of warfarin; if chronic alcohol abuse results in significant liver damage, action of warfarin may be ↑ due to ↓ production of clotting factor.
• Acute alcohol ingestion may ↑ action of warfarin.
• Barbiturates, carbamazepine, rifampin, and hormonal contraceptives containing estrogen may ↓ the anticoagulant response to warfarin.
• Many other drugs may affect the activity of warfarin.

Drug-Natural Products:

• St. John’s wort ↓ effect.
• ↑bleeding risk with anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, licorice, and others.

Drug-Food:

• Ingestion of large quantities of foods high in vitamin K content (see list in Appendix M) may antagonize the anticoagulant effect of warfarin.

• PO (Adults): 2–5 mg/day for 2–4 days; then adjust daily dose by results of INR. Initiate therapy with lower doses in geriatric or debilitated patients or in Asian patients or those with CYP2C9*2 and/or CYP2C9*3 alleles or VKORC1 AA genotype.
• PO (Children >1 mo): Initial loading dose — 0.2 mg/kg (maximum dose: 10 mg) for 2–4 days then adjust daily dose by results of INR, use 0.1 mg/kg if liver dysfunction is present. Maintenance dose range — 0.05–0.34 mg/kg/day.

• High Alert:Do not confuse Coumadin (warfarin) with Avandia (rosiglitazone) or Cardura (doxazosin). Do not confuse Jantoven (warfarin) with Janumet (sitagliptin/metformin) or Januvia (sitagliptin).
• Because of the large number of medications capable of significantly altering warfarin’s effects, careful monitoring is recommended when new agents are started or other agents are discontinued. Interactive potential should be evaluated for all new medications (Rx, OTC, and herbal products).
• PO: Administer medication at same time each day. Medication requires 3–5 days to reach effective levels; usually begun while patient is still on heparin.
  • Do not interchange brands; potencies may not be equivalent.

Coumadin, Jantoven

Therapeutic Classification: anticoagulants

Pharmacologic Classification: coumarins

(Generic available)

• Tablets: 1 mg; 2 mg; 2.5 mg; 3 mg; 4 mg; 5 mg; 6 mg; 7.5 mg; 10 mg;
  • Cost: Generic— 1 mg; $10.83/100 2 mg; $10.83/100 2.5 mg; $10.83/100 3 mg; $10.83/100 4 mg; $10.83/100 5 mg; $8.52/100 6 mg; $10.64/100 7.5 mg; $10.83/100 10 mg; $10.83/100.

(effects on coagulation tests)

• Assess for signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; tarry, black stools; hematuria; fall in hematocrit or BP; guaiac-positive stools, urine, or nasogastric aspirate).
• Assess for evidence of additional or increased thrombosis. Symptoms depend on area of involvement.

• Monitor PT, INR and other clotting factors frequently during therapy; monitor more frequently in patients with renal impairment. Therapeutic PT ranges 1.3–1.5 times greater than control; however, the INR, a standardized system that provides a common basis for communicating and interpreting PT results, is usually referenced. Normal INR (not on anticoagulants) is 0.8–1.2. An INR of 2.5–3.5 is recommended for patients at very high risk of embolization (for example, patients with mitral valve replacement and ventricular hypertrophy). Lower levels are acceptable when risk is lower. Heparin may affect the PT/INR; draw blood for PT/INR in patients receiving both heparin and warfarin at least 5 hr after the IV bolus dose, 4 hr after cessation of IV infusion, or 24 hr after subcut heparin injection. Asian patients and those who carry the CYP2C9*2 allele and/or the CYP2C9*3 allele, or those with VKORC1 AA genotype may require more frequent monitoring and lower doses.
  • Geri: Patients over 60 yr exhibit greater than expected PT/INR response. Monitor for side effects at lower therapeutic ranges
  • Pedi: Achieving and maintaining therapeutic PT/INR ranges may be more difficult in pediatric patients. Assess PT/INR levels more frequently
  • Monitor hepatic function and CBC before and periodically throughout therapy.
  • Monitor stool and urine for occult blood before and periodically during therapy.

• Withholding 1 or more doses of warfarin is usually sufficient if INR is excessively elevated or if minor bleeding occurs. If overdose occurs or anticoagulation needs to be immediately reversed, the antidote is vitamin K (phytonadione, Aquamephyton). Administration of whole blood or plasma also may be required in severe bleeding because of the delayed onset of vitamin K.

• Instruct patient to take medication as directed. Take missed doses as soon as remembered that day; do not double doses. Inform health care professional of missed doses at time of checkup or lab tests. Inform patients that anticoagulant effect may persist for 2–5 days following discontinuation. Advise patient to read Medication Guide before starting therapy and with each Rx refill in case of changes.
• Review foods high in vitamin K (see Appendix M). Patient should have consistent limited intake of these foods, as vitamin K is the antidote for warfarin, and alternating intake of these foods will cause PT levels to fluctuate. Advise patient to avoid cranberry juice or products during therapy.
• Caution patient to avoid IM injections and activities leading to injury. Instruct patient to use a soft toothbrush, not to floss, and to shave with an electric razor during warfarin therapy. Advise patient that venipunctures and injection sites require application of pressure to prevent bleeding or hematoma formation.
• Advise patient to report any symptoms of unusual bleeding or bruising (bleeding gums; nosebleed; black, tarry stools; hematuria; excessive menstrual flow) and pain, color, or temperature change to any area of your body to health care professional immediately.Patients with a deficiency in protein C and/or S mediated anticoagulant response may be at greater risk for tissue necrosis.
• Instruct patient not to drink alcohol or take other Rx, OTC, or herbal products, especially those containing aspirin or NSAIDs, or to start or stop any new medications during warfarin therapy without advice of health care professional.
• Rep: May cause fetal harm. Advise females of reproductive potential to use effective contraception during and for 1 month after last dose. Advise patient to notify health care professional if pregnancy is planned or suspected or if breast feeding.
• Instruct patient to carry identification describing medication regimen at all times and to inform all health care personnel caring for patient on anticoagulant therapy before lab tests, treatment, or surgery.
• Emphasize the importance of frequent lab tests to monitor coagulation factors.

• Prolonged PT (1.3–2.0 times the control; may vary with indication) or INR of 2–4.5 without signs of hemorrhage.

NDC Code^*

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0168- COUMADIN
    • 0056-0168-01- 10 TABLET in 1 BLISTER PACK (0056-0168-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0168- COUMADIN
    • 0056-0168-70- 1 BOTTLE in 1 CARTON (0056-0168-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0168- COUMADIN
    • 0056-0168-75- 10 BLISTER PACK in 1 CARTON (0056-0168-75) > 10 TABLET in 1 BLISTER PACK (0056-0168-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0169- COUMADIN
    • 0056-0169-01- 10 TABLET in 1 BLISTER PACK (0056-0169-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0169- COUMADIN
    • 0056-0169-70- 1 BOTTLE in 1 CARTON (0056-0169-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0169- COUMADIN
    • 0056-0169-75- 10 BLISTER PACK in 1 CARTON (0056-0169-75) > 10 TABLET in 1 BLISTER PACK (0056-0169-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0169- COUMADIN
    • 0056-0169-90- 1 BOTTLE in 1 CARTON (0056-0169-90) > 1000 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0170- COUMADIN
    • 0056-0170-01- 10 TABLET in 1 BLISTER PACK (0056-0170-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0170- COUMADIN
    • 0056-0170-70- 1 BOTTLE in 1 CARTON (0056-0170-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0170- COUMADIN
    • 0056-0170-75- 10 BLISTER PACK in 1 CARTON (0056-0170-75) > 10 TABLET in 1 BLISTER PACK (0056-0170-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0170- COUMADIN
    • 0056-0170-90- 1 BOTTLE in 1 CARTON (0056-0170-90) > 1000 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0172- COUMADIN
    • 0056-0172-01- 10 TABLET in 1 BLISTER PACK (0056-0172-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0172- COUMADIN
    • 0056-0172-70- 1 BOTTLE in 1 CARTON (0056-0172-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0172- COUMADIN
    • 0056-0172-75- 10 BLISTER PACK in 1 CARTON (0056-0172-75) > 10 TABLET in 1 BLISTER PACK (0056-0172-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0172- COUMADIN
    • 0056-0172-90- 1 BOTTLE in 1 CARTON (0056-0172-90) > 1000 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0173- COUMADIN
    • 0056-0173-01- 10 TABLET in 1 BLISTER PACK (0056-0173-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0173- COUMADIN
    • 0056-0173-70- 1 BOTTLE in 1 CARTON (0056-0173-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0173- COUMADIN
    • 0056-0173-75- 10 BLISTER PACK in 1 CARTON (0056-0173-75) > 10 TABLET in 1 BLISTER PACK (0056-0173-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0174- COUMADIN
    • 0056-0174-01- 10 TABLET in 1 BLISTER PACK (0056-0174-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0174- COUMADIN
    • 0056-0174-70- 1 BOTTLE in 1 CARTON (0056-0174-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0174- COUMADIN
    • 0056-0174-75- 10 BLISTER PACK in 1 CARTON (0056-0174-75) > 10 TABLET in 1 BLISTER PACK (0056-0174-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0176- COUMADIN
    • 0056-0176-01- 10 TABLET in 1 BLISTER PACK (0056-0176-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0176- COUMADIN
    • 0056-0176-70- 1 BOTTLE in 1 CARTON (0056-0176-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0176- COUMADIN
    • 0056-0176-75- 10 BLISTER PACK in 1 CARTON (0056-0176-75) > 10 TABLET in 1 BLISTER PACK (0056-0176-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0176- COUMADIN
    • 0056-0176-90- 1 BOTTLE in 1 CARTON (0056-0176-90) > 1000 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0188- COUMADIN
    • 0056-0188-01- 10 TABLET in 1 BLISTER PACK (0056-0188-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0188- COUMADIN
    • 0056-0188-70- 1 BOTTLE in 1 CARTON (0056-0188-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0188- COUMADIN
    • 0056-0188-75- 10 BLISTER PACK in 1 CARTON (0056-0188-75) > 10 TABLET in 1 BLISTER PACK (0056-0188-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0189- COUMADIN
    • 0056-0189-01- 10 TABLET in 1 BLISTER PACK (0056-0189-01)

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0189- COUMADIN
    • 0056-0189-70- 1 BOTTLE in 1 CARTON (0056-0189-70) > 100 TABLET in 1 BOTTLE

• 0056- Bristol-Myers Squibb Pharma Company
  • 0056-0189- COUMADIN
    • 0056-0189-75- 10 BLISTER PACK in 1 CARTON (0056-0189-75) > 10 TABLET in 1 BLISTER PACK (0056-0189-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1712- Warfarin Sodium
    • 0093-1712-01- 100 TABLET in 1 BOTTLE (0093-1712-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1712- Warfarin Sodium
    • 0093-1712-10- 1000 TABLET in 1 BOTTLE (0093-1712-10)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1713- Warfarin Sodium
    • 0093-1713-01- 100 TABLET in 1 BOTTLE (0093-1713-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1713- Warfarin Sodium
    • 0093-1713-10- 1000 TABLET in 1 BOTTLE (0093-1713-10)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1714- Warfarin Sodium
    • 0093-1714-01- 100 TABLET in 1 BOTTLE (0093-1714-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1714- Warfarin Sodium
    • 0093-1714-10- 1000 TABLET in 1 BOTTLE (0093-1714-10)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1715- Warfarin Sodium
    • 0093-1715-01- 100 TABLET in 1 BOTTLE (0093-1715-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1716- Warfarin Sodium
    • 0093-1716-01- 100 TABLET in 1 BOTTLE (0093-1716-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1716- Warfarin Sodium
    • 0093-1716-10- 1000 TABLET in 1 BOTTLE (0093-1716-10)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1718- Warfarin Sodium
    • 0093-1718-01- 100 TABLET in 1 BOTTLE (0093-1718-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1719- Warfarin Sodium
    • 0093-1719-01- 100 TABLET in 1 BOTTLE (0093-1719-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-17,20- Warfarin Sodium
    • 0093-17,20-01- 100 TABLET in 1 BOTTLE (0093-17,20-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1721- Warfarin Sodium
    • 0093-1721-01- 100 TABLET in 1 BOTTLE (0093-1721-01)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1721- Warfarin Sodium
    • 0093-1721-10- 1000 TABLET in 1 BOTTLE (0093-1721-10)

• 0093- Teva Pharmaceuticals USA, Inc.
  • 0093-1723- Warfarin Sodium
    • 0093-1723-01- 100 TABLET in 1 BOTTLE (0093-1723-01)

• 0555- Teva Pharmaceuticals USA, Inc.
  • 0555-0834- Warfarin Sodium
    • 0555-0834-02- 100 TABLET in 1 BOTTLE (0555-0834-02)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1211- Jantoven
    • 0832-1211-00- 100 TABLET in 1 BOTTLE (0832-1211-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1211- Jantoven
    • 0832-1211-01- 100 BLISTER PACK in 1 CARTON (0832-1211-01) > 1 TABLET in 1 BLISTER PACK (0832-1211-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1211- Jantoven
    • 0832-1211-10- 1000 TABLET in 1 BOTTLE (0832-1211-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1212- Jantoven
    • 0832-1212-00- 100 TABLET in 1 BOTTLE (0832-1212-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1212- Jantoven
    • 0832-1212-01- 100 BLISTER PACK in 1 CARTON (0832-1212-01) > 1 TABLET in 1 BLISTER PACK (0832-1212-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1212- Jantoven
    • 0832-1212-10- 1000 TABLET in 1 BOTTLE (0832-1212-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1213- Jantoven
    • 0832-1213-00- 100 TABLET in 1 BOTTLE (0832-1213-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1213- Jantoven
    • 0832-1213-01- 100 BLISTER PACK in 1 CARTON (0832-1213-01) > 1 TABLET in 1 BLISTER PACK (0832-1213-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1213- Jantoven
    • 0832-1213-10- 1000 TABLET in 1 BOTTLE (0832-1213-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1214- Jantoven
    • 0832-1214-00- 100 TABLET in 1 BOTTLE (0832-1214-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1214- Jantoven
    • 0832-1214-01- 100 BLISTER PACK in 1 CARTON (0832-1214-01) > 1 TABLET in 1 BLISTER PACK (0832-1214-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1214- Jantoven
    • 0832-1214-10- 1000 TABLET in 1 BOTTLE (0832-1214-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1215- Jantoven
    • 0832-1215-00- 100 TABLET in 1 BOTTLE (0832-1215-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1215- Jantoven
    • 0832-1215-01- 100 BLISTER PACK in 1 CARTON (0832-1215-01) > 1 TABLET in 1 BLISTER PACK (0832-1215-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1215- Jantoven
    • 0832-1215-10- 1000 TABLET in 1 BOTTLE (0832-1215-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1216- Jantoven
    • 0832-1216-00- 100 TABLET in 1 BOTTLE (0832-1216-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1216- Jantoven
    • 0832-1216-01- 100 BLISTER PACK in 1 CARTON (0832-1216-01) > 1 TABLET in 1 BLISTER PACK (0832-1216-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1216- Jantoven
    • 0832-1216-10- 1000 TABLET in 1 BOTTLE (0832-1216-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1217- Jantoven
    • 0832-1217-00- 100 TABLET in 1 BOTTLE (0832-1217-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1217- Jantoven
    • 0832-1217-01- 100 BLISTER PACK in 1 CARTON (0832-1217-01) > 1 TABLET in 1 BLISTER PACK (0832-1217-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1217- Jantoven
    • 0832-1217-10- 1000 TABLET in 1 BOTTLE (0832-1217-10)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1218- Jantoven
    • 0832-1218-00- 100 TABLET in 1 BOTTLE (0832-1218-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1218- Jantoven
    • 0832-1218-01- 100 BLISTER PACK in 1 CARTON (0832-1218-01) > 1 TABLET in 1 BLISTER PACK (0832-1218-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1218- Jantoven
    • 0832-1218-50- 500 TABLET in 1 BOTTLE (0832-1218-50)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1219- Jantoven
    • 0832-1219-00- 100 TABLET in 1 BOTTLE (0832-1219-00)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1219- Jantoven
    • 0832-1219-01- 100 BLISTER PACK in 1 CARTON (0832-1219-01) > 1 TABLET in 1 BLISTER PACK (0832-1219-89)

• 0832- Upsher-Smith Laboratories, LLC
  • 0832-1219- Jantoven
    • 0832-1219-50- 500 TABLET in 1 BOTTLE (0832-1219-50)

• 17856- ATLANTIC BIOLOGICALS CORP.
  • 17856-4034- Warfarin Sodium
    • 17856-4034-1- 100 POUCH in 1 BOX, UNIT-DOSE (17856-4034-1) > 1 TABLET in 1 POUCH

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-355- Warfarin Sodium
    • 33261-355-00- 100 TABLET in 1 BOTTLE, PLASTIC (33261-355-00)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-355- Warfarin Sodium
    • 33261-355-30- 30 TABLET in 1 BOTTLE, PLASTIC (33261-355-30)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-356- Warfarin Sodium
    • 33261-356-30- 30 TABLET in 1 BOTTLE, PLASTIC (33261-356-30)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-356- Warfarin Sodium
    • 33261-356-90- 90 TABLET in 1 BOTTLE, PLASTIC (33261-356-90)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-357- Warfarin Sodium
    • 33261-357-10- 10 TABLET in 1 BOTTLE, PLASTIC (33261-357-10)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-357- Warfarin Sodium
    • 33261-357-30- 30 TABLET in 1 BOTTLE, PLASTIC (33261-357-30)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-357- Warfarin Sodium
    • 33261-357-60- 60 TABLET in 1 BOTTLE, PLASTIC (33261-357-60)

• 33261- Aidarex Pharmaceuticals LLC
  • 33261-357- Warfarin Sodium
    • 33261-357-90- 90 TABLET in 1 BOTTLE, PLASTIC (33261-357-90)

• 43063- PD-Rx Pharmaceuticals, Inc.
  • 43063-176- Warfarin Sodium
    • 43063-176-14- 14 TABLET in 1 BOTTLE, PLASTIC (43063-176-14)

• 43063- PD-Rx Pharmaceuticals, Inc.
  • 43063-176- Warfarin Sodium
    • 43063-176-30- 30 TABLET in 1 BOTTLE, PLASTIC (43063-176-30)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-30- 30 TABLET in 1 BOTTLE (43353-021-30)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-35- 35 TABLET in 1 BOTTLE (43353-021-35)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-40- 40 TABLET in 1 BOTTLE (43353-021-40)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-45- 45 TABLET in 1 BOTTLE (43353-021-45)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-50- 50 TABLET in 1 BOTTLE (43353-021-50)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
    • 43353-021-53- 60 TABLET in 1 BOTTLE (43353-021-53)

• 43353- Aphena Pharma Solutions - Tennessee, LLC
  • 43353-021- Warfarin Sodium
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• 51672- Taro Pharmaceuticals U.S.A., Inc.
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    • 51672-4032-0- 10 BLISTER PACK in 1 CARTON (51672-4032-0) > 10 TABLET in 1 BLISTER PACK

• 51672- Taro Pharmaceuticals U.S.A., Inc.
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• 51672- Taro Pharmaceuticals U.S.A., Inc.
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    • 51672-4032-3- 1000 TABLET in 1 BOTTLE (51672-4032-3)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4032- Warfarin Sodium
    • 51672-4032-7- 5000 TABLET in 1 BOTTLE (51672-4032-7)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4033- Warfarin Sodium
    • 51672-4033-0- 10 BLISTER PACK in 1 CARTON (51672-4033-0) > 10 TABLET in 1 BLISTER PACK

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4033- Warfarin Sodium
    • 51672-4033-1- 100 TABLET in 1 BOTTLE (51672-4033-1)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4033- Warfarin Sodium
    • 51672-4033-3- 1000 TABLET in 1 BOTTLE (51672-4033-3)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4033- Warfarin Sodium
    • 51672-4033-7- 5000 TABLET in 1 BOTTLE (51672-4033-7)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4034- Warfarin Sodium
    • 51672-4034-0- 10 BLISTER PACK in 1 CARTON (51672-4034-0) > 10 TABLET in 1 BLISTER PACK

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4034- Warfarin Sodium
    • 51672-4034-1- 100 TABLET in 1 BOTTLE (51672-4034-1)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4034- Warfarin Sodium
    • 51672-4034-3- 1000 TABLET in 1 BOTTLE (51672-4034-3)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4035- Warfarin Sodium
    • 51672-4035-0- 10 BLISTER PACK in 1 CARTON (51672-4035-0) > 10 TABLET in 1 BLISTER PACK

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4035- Warfarin Sodium
    • 51672-4035-1- 100 TABLET in 1 BOTTLE (51672-4035-1)

• 51672- Taro Pharmaceuticals U.S.A., Inc.
  • 51672-4035- Warfarin Sodium
    • 51672-4035-3- 1000 TABLET in 1 BOTTLE (51672-4035-3)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-001- Warfarin Sodium
    • 53217-001-07- 7 TABLET in 1 BOTTLE, PLASTIC (53217-001-07)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-001- Warfarin Sodium
    • 53217-001-14- 14 TABLET in 1 BOTTLE, PLASTIC (53217-001-14)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-001- Warfarin Sodium
    • 53217-001-30- 30 TABLET in 1 BOTTLE, PLASTIC (53217-001-30)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-001- Warfarin Sodium
    • 53217-001-60- 60 TABLET in 1 BOTTLE, PLASTIC (53217-001-60)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-001- Warfarin Sodium
    • 53217-001-90- 90 TABLET in 1 BOTTLE, PLASTIC (53217-001-90)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-018- Warfarin Sodium
    • 53217-018-07- 7 TABLET in 1 BOTTLE, PLASTIC (53217-018-07)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-018- Warfarin Sodium
    • 53217-018-14- 14 TABLET in 1 BOTTLE, PLASTIC (53217-018-14)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-018- Warfarin Sodium
    • 53217-018-30- 30 TABLET in 1 BOTTLE, PLASTIC (53217-018-30)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-018- Warfarin Sodium
    • 53217-018-60- 60 TABLET in 1 BOTTLE, PLASTIC (53217-018-60)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-018- Warfarin Sodium
    • 53217-018-90- 90 TABLET in 1 BOTTLE, PLASTIC (53217-018-90)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-219- Warfarin Sodium
    • 53217-219-30- 30 TABLET in 1 BOTTLE (53217-219-30)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-219- Warfarin Sodium
    • 53217-219-60- 60 TABLET in 1 BOTTLE (53217-219-60)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-219- Warfarin Sodium
    • 53217-219-90- 90 TABLET in 1 BOTTLE (53217-219-90)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-235- Warfarin Sodium
    • 53217-235-30- 30 TABLET in 1 BOTTLE (53217-235-30)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-235- Warfarin Sodium
    • 53217-235-60- 60 TABLET in 1 BOTTLE (53217-235-60)

• 53217- Aidarex Pharmaceuticals LLC
  • 53217-235- Warfarin Sodium
    • 53217-235-90- 90 TABLET in 1 BOTTLE (53217-235-90)

• 55154- Cardinal Health
  • 55154-4695- Warfarin Sodium
    • 55154-4695-0- 10 BLISTER PACK in 1 BAG (55154-4695-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-4696- Warfarin Sodium
    • 55154-4696-0- 10 BLISTER PACK in 1 BAG (55154-4696-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-4697- Warfarin Sodium
    • 55154-4697-0- 10 BLISTER PACK in 1 BAG (55154-4697-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7701- COUMADIN
    • 55154-7701-0- 10 BLISTER PACK in 1 BAG (55154-7701-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7702- COUMADIN
    • 55154-7702-0- 10 BLISTER PACK in 1 BAG (55154-7702-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7703- COUMADIN
    • 55154-7703-0- 10 BLISTER PACK in 1 BAG (55154-7703-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7704- COUMADIN
    • 55154-7704-0- 10 BLISTER PACK in 1 BAG (55154-7704-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7706- COUMADIN
    • 55154-7706-0- 10 BLISTER PACK in 1 BAG (55154-7706-0) > 1 TABLET in 1 BLISTER PACK

• 55154- Cardinal Health
  • 55154-7716- COUMADIN
    • 55154-7716-0- 10 BLISTER PACK in 1 BAG (55154-7716-0) > 1 TABLET in 1 BLISTER PACK

• 57237- Rising Health, LLC
  • 57237-119- Warfarin Sodium
    • 57237-119-01- 100 TABLET in 1 BOTTLE (57237-119-01)

• 57237- Rising Health, LLC
  • 57237-119- Warfarin Sodium
    • 57237-119-90- 90 TABLET in 1 BOTTLE (57237-119-90)

• 57237- Rising Health, LLC
  • 57237-119- Warfarin Sodium
    • 57237-119-99- 1000 TABLET in 1 BOTTLE (57237-119-99)

• 57237- Rising Health, LLC
  • 57237-120- Warfarin Sodium
    • 57237-120-01- 100 TABLET in 1 BOTTLE (57237-120-01)

• 57237- Rising Health, LLC
  • 57237-120- Warfarin Sodium
    • 57237-120-90- 90 TABLET in 1 BOTTLE (57237-120-90)

• 57237- Rising Health, LLC
  • 57237-120- Warfarin Sodium
    • 57237-120-99- 1000 TABLET in 1 BOTTLE (57237-120-99)

• 57237- Rising Health, LLC
  • 57237-121- Warfarin Sodium
    • 57237-121-01- 100 TABLET in 1 BOTTLE (57237-121-01)

• 57237- Rising Health, LLC
  • 57237-121- Warfarin Sodium
    • 57237-121-90- 90 TABLET in 1 BOTTLE (57237-121-90)

• 57237- Rising Health, LLC
  • 57237-121- Warfarin Sodium
    • 57237-121-99- 1000 TABLET in 1 BOTTLE (57237-121-99)

• 57237- Rising Health, LLC
  • 57237-122- Warfarin Sodium
    • 57237-122-01- 100 TABLET in 1 BOTTLE (57237-122-01)

• 57237- Rising Health, LLC
  • 57237-122- Warfarin Sodium
    • 57237-122-90- 90 TABLET in 1 BOTTLE (57237-122-90)

• 57237- Rising Health, LLC
  • 57237-122- Warfarin Sodium
    • 57237-122-99- 1000 TABLET in 1 BOTTLE (57237-122-99)

• 57237- Rising Health, LLC
  • 57237-123- Warfarin Sodium
    • 57237-123-01- 100 TABLET in 1 BOTTLE (57237-123-01)

• 57237- Rising Health, LLC
  • 57237-123- Warfarin Sodium
    • 57237-123-90- 90 TABLET in 1 BOTTLE (57237-123-90)

• 57237- Rising Health, LLC
  • 57237-123- Warfarin Sodium
    • 57237-123-99- 1000 TABLET in 1 BOTTLE (57237-123-99)

• 57237- Rising Health, LLC
  • 57237-124- Warfarin Sodium
    • 57237-124-01- 100 TABLET in 1 BOTTLE (57237-124-01)

• 57237- Rising Health, LLC
  • 57237-124- Warfarin Sodium
    • 57237-124-90- 90 TABLET in 1 BOTTLE (57237-124-90)

• 57237- Rising Health, LLC
  • 57237-124- Warfarin Sodium
    • 57237-124-99- 1000 TABLET in 1 BOTTLE (57237-124-99)

• 57237- Rising Health, LLC
  • 57237-125- Warfarin Sodium
    • 57237-125-01- 100 TABLET in 1 BOTTLE (57237-125-01)

• 57237- Rising Health, LLC
  • 57237-125- Warfarin Sodium
    • 57237-125-90- 90 TABLET in 1 BOTTLE (57237-125-90)

• 57237- Rising Health, LLC
  • 57237-125- Warfarin Sodium
    • 57237-125-99- 1000 TABLET in 1 BOTTLE (57237-125-99)

• 57237- Rising Health, LLC
  • 57237-126- Warfarin Sodium
    • 57237-126-01- 100 TABLET in 1 BOTTLE (57237-126-01)

• 57237- Rising Health, LLC
  • 57237-126- Warfarin Sodium
    • 57237-126-90- 90 TABLET in 1 BOTTLE (57237-126-90)

• 57237- Rising Health, LLC
  • 57237-126- Warfarin Sodium
    • 57237-126-99- 1000 TABLET in 1 BOTTLE (57237-126-99)

• 57237- Rising Health, LLC
  • 57237-127- Warfarin Sodium
    • 57237-127-01- 100 TABLET in 1 BOTTLE (57237-127-01)

• 57237- Rising Health, LLC
  • 57237-127- Warfarin Sodium
    • 57237-127-90- 90 TABLET in 1 BOTTLE (57237-127-90)

• 57237- Rising Health, LLC
  • 57237-127- Warfarin Sodium
    • 57237-127-99- 1000 TABLET in 1 BOTTLE (57237-127-99)

• 58118- Clinical Solutions Wholesale, LLC
  • 58118-0041- Warfarin Sodium
    • 58118-0041-8- 30 TABLET in 1 BLISTER PACK (58118-0041-8)

• 60760- St. Mary's Medical Park Pharmacy
  • 60760-706- Warfarin Sodium
    • 60760-706-30- 30 TABLET in 1 BOTTLE, PLASTIC (60760-706-30)

• 62584- American Health Packaging
  • 62584-984- Warfarin Sodium
    • 62584-984-01- 100 BLISTER PACK in 1 BOX, UNIT-DOSE (62584-984-01) > 1 TABLET in 1 BLISTER PACK (62584-984-11)

• 62584- American Health Packaging
  • 62584-994- Warfarin Sodium
    • 62584-994-01- 100 BLISTER PACK in 1 BOX, UNIT-DOSE (62584-994-01) > 1 TABLET in 1 BLISTER PACK (62584-994-11)

• 63187- Proficient Rx LP
  • 63187-674- Warfarin Sodium
    • 63187-674-00- 100 TABLET in 1 BOTTLE (63187-674-00)

• 63187- Proficient Rx LP
  • 63187-674- Warfarin Sodium
    • 63187-674-10- 10 TABLET in 1 BAG (63187-674-10)

• 63187- Proficient Rx LP
  • 63187-674- Warfarin Sodium
    • 63187-674-30- 30 TABLET in 1 BOTTLE (63187-674-30)

• 63187- Proficient Rx LP
  • 63187-674- Warfarin Sodium
    • 63187-674-60- 60 TABLET in 1 BOTTLE (63187-674-60)

• 63187- Proficient Rx LP
  • 63187-674- Warfarin Sodium
    • 63187-674-90- 90 TABLET in 1 BOTTLE (63187-674-90)

• 63187- Proficient Rx LP
  • 63187-745- Warfarin Sodium
    • 63187-745-10- 10 TABLET in 1 BOTTLE (63187-745-10)

• 63187- Proficient Rx LP
  • 63187-745- Warfarin Sodium
    • 63187-745-30- 30 TABLET in 1 BOTTLE (63187-745-30)

• 63187- Proficient Rx LP
  • 63187-745- Warfarin Sodium
    • 63187-745-60- 60 TABLET in 1 BOTTLE (63187-745-60)

• 63187- Proficient Rx LP
  • 63187-745- Warfarin Sodium
    • 63187-745-90- 90 TABLET in 1 BOTTLE (63187-745-90)

• 63187- Proficient Rx LP
  • 63187-750- Warfarin Sodium
    • 63187-750-10- 10 TABLET in 1 BOTTLE (63187-750-10)

• 63187- Proficient Rx LP
  • 63187-750- Warfarin Sodium
    • 63187-750-30- 30 TABLET in 1 BOTTLE (63187-750-30)

• 63187- Proficient Rx LP
  • 63187-750- Warfarin Sodium
    • 63187-750-60- 60 TABLET in 1 BOTTLE (63187-750-60)

• 63187- Proficient Rx LP
  • 63187-750- Warfarin Sodium
    • 63187-750-90- 90 TABLET in 1 BOTTLE (63187-750-90)

• 63629- Bryant Ranch Prepack
  • 63629-3177- Warfarin Sodium
    • 63629-3177-1- 30 TABLET in 1 BOTTLE (63629-3177-1)

• 63629- Bryant Ranch Prepack
  • 63629-3177- Warfarin Sodium
    • 63629-3177-2- 60 TABLET in 1 BOTTLE (63629-3177-2)

• 63629- Bryant Ranch Prepack
  • 63629-3177- Warfarin Sodium
    • 63629-3177-3- 15 TABLET in 1 BOTTLE (63629-3177-3)

• 63629- Bryant Ranch Prepack
  • 63629-3177- Warfarin Sodium
    • 63629-3177-4- 90 TABLET in 1 BOTTLE (63629-3177-4)

• 63629- Bryant Ranch Prepack
  • 63629-3177- Warfarin Sodium
    • 63629-3177-5- 100 TABLET in 1 BOTTLE (63629-3177-5)

• 63629- Bryant Ranch Prepack
  • 63629-6342- Warfarin Sodium
    • 63629-6342-1- 60 TABLET in 1 BOTTLE (63629-6342-1)

• 63629- Bryant Ranch Prepack
  • 63629-6342- Warfarin Sodium
    • 63629-6342-2- 90 TABLET in 1 BOTTLE (63629-6342-2)

• 63629- Bryant Ranch Prepack
  • 63629-6400- Warfarin Sodium
    • 63629-6400-1- 30 TABLET in 1 BOTTLE (63629-6400-1)

• 63629- Bryant Ranch Prepack
  • 63629-6977- Warfarin Sodium
    • 63629-6977-1- 30 TABLET in 1 BOTTLE (63629-6977-1)

• 63629- Bryant Ranch Prepack
  • 63629-6977- Warfarin Sodium
    • 63629-6977-2- 90 TABLET in 1 BOTTLE (63629-6977-2)

• 63629- Bryant Ranch Prepack
  • 63629-8146- Warfarin Sodium
    • 63629-8146-1- 30 TABLET in 1 BOTTLE (63629-8146-1)

• 63629- Bryant Ranch Prepack
  • 63629-8147- Warfarin Sodium
    • 63629-8147-1- 30 TABLET in 1 BOTTLE (63629-8147-1)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-761- Warfarin Sodium
    • 65162-761-10- 100 TABLET in 1 BOTTLE (65162-761-10)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-761- Warfarin Sodium
    • 65162-761-11- 1000 TABLET in 1 BOTTLE (65162-761-11)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-761- Warfarin Sodium
    • 65162-761-50- 500 TABLET in 1 BOTTLE (65162-761-50)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-762- Warfarin Sodium
    • 65162-762-10- 100 TABLET in 1 BOTTLE (65162-762-10)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-762- Warfarin Sodium
    • 65162-762-11- 1000 TABLET in 1 BOTTLE (65162-762-11)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-762- Warfarin Sodium
    • 65162-762-50- 500 TABLET in 1 BOTTLE (65162-762-50)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-763- Warfarin Sodium
    • 65162-763-10- 100 TABLET in 1 BOTTLE (65162-763-10)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-763- Warfarin Sodium
    • 65162-763-11- 1000 TABLET in 1 BOTTLE (65162-763-11)

• 65162- Amneal Pharmaceuticals LLC
  • 65162-763- Warfarin Sodium
    • 65162-763-50- 500 TABLET in 1 BOTTLE (65162-763-50)