ka-pe-SITE-a-been 
Absorption: Well absorbed after oral administration.
Distribution: Unknown.
Metabolism/Excretion: Metabolized mostly in tissue and by the liver to 5-fluorouracil; 5-fluorouracil is metabolized by dihydropyrimidine dehydrogenase to a less toxic compound; inactive metabolites are excreted primarily in urine.
Half-life: 45 min.
Contraindicated in:
Use Cautiously in:
80 yr.CV: edema, chest pain.
Derm: STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, dermatitis, hand-and-foot syndrome, nail disorder, alopecia, erythema, rashes.
EENT: eye irritation, epistaxis, rhinorrhea.
F and E: dehydration.
GI: diarrhea, NECROTIZING ENTEROCOLITIS, abdominal pain, anorexia, constipation, hyperbilirubinemia, nausea, stomatitis, vomiting, dyspepsia, xerostomia.
GU: acute renal failure, ↓ fertility.
Hemat: anemia, leukopenia, thrombocytopenia.
MS: arthralgia, myalgia.
Neuro: dysgeusia, peripheral neuropathy, fatigue, headache, dizziness, insomnia.
Misc: fever.
Drug-Drug:
Drug-Food:
Renal Impairment
10 stools/day or grossly bloody diarrhea or need for parenteral support). If grade 2, 3, or 4 diarrhea occurs, immediately stop therapy until diarrhea resolves or decreases in intensity to Grade 1. Grade 3 or 4 diarrhea usually lasts 5 days.100.5° F or other signs of infection).NDC Code*