oh-FLOX-a-sin 
Spectrum:
Absorption: Well absorbed (98%) following oral administration.
Distribution: Widely distributed. High tissue and urinary levels are achieved. Appears to cross the placenta; enters breast milk.
Metabolism/Excretion: 70–80% excreted unchanged by the kidneys.
Half-life: 5–7 hr.
Contraindicated in:
Use Cautiously in:
50 mL/min)CV: AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES, QT interval prolongation.
Derm: STEVENS-JOHNSON SYNDROME, photosensitivity, rash.
Endo: hyperglycemia, hypoglycemia.
GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), abdominal pain, diarrhea, nausea, vomiting.
GU: vaginitis.
MS: arthralgia, myalgia, tendinitis, tendon rupture.
Neuro: peripheral neuropathy , ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), SEIZURES, SUICIDAL THOUGHTS, agitation, anxiety, confusion, depression, dizziness, hallucinations, headache, insomnia, nightmares, paranoia, toxic psychosis, tremor.
Drug-Drug:
Drug-Food:
Acute Bacterial Exacerbations of Chronic Bronchitis
Community-Acquired Pneumonia
Uncomplicated Skin/Skin Structure Infections
Uncomplicated Urethral and Cervical Gonorrhea
Nongonococcal Urethritis/Cervicitis
Mixed Infection of the Urethra and Cervix
Acute Pelvic Inflammatory Disease
Urinary Tract Infections
Prostatitis
Renal Impairment
6 mo): Otitis externa 6 mo to 13 yr — : 5 drops instilled into affected ear once daily for 7 days; Otitis externa 13 yr — 10 drops instilled into affected ear once daily for 7 days. Acute otitis media in patients 1–12 yr old with tympanostomy tubes: 5 drops instilled into the affected ear twice daily for 10 days. Chronic suppurative otitis media with perforated tympanic membranes in patients 12 yr: 10 drops instilled into the affected ear twice daily for 14 days.Floxin, Floxin Otic
NDC Code*