min-oh-SYE-kleen 
Spectrum:
Absorption: Well absorbed from the GI tract. IV administration results in complete bioavailability.
Distribution: Widely distributed, some CSF and good bone penetration; crosses the placenta and enters breast milk.
Metabolism/Excretion: 5–20% excreted unchanged by the urine; some metabolism by the liver with enterohepatic circulation and excretion in bile and feces.
Half-life: 11–26 hr.
Contraindicated in:
Use Cautiously in:
CNS: intracranial hypertension, dizziness.
EENT: vestibular reactions.
GI: HEPATOTOXICITY, CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, vomiting, esophagitis, pancreatitis.
Derm: DRUG RASH WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS SYNDROME (DRESS), ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, photosensitivity, rash, pigmentation of skin and mucous membranes.
Endo: thyroid disorders.
Hemat: blood dyscrasias.
MS: lupus-like syndrome.
Misc: hypersensitivity reactions, superinfection.
Drug-Drug:
Drug-Food:
8 yr): 4 mg/kg initially, then 2 mg/kg q 12 hr.12 yrs [Solodyn and Ximino]): 126–136 kg135 mg once daily for 12 wks; 111–125 kg — 115 mg once daily for 12 wks; 97–110 kg — 105 mg once daily for 12 wks; 85–96 kg — 90 mg once daily for 12 wks; 72–84 kg — 80 mg once daily for 12 wks; 60–71 kg — 65 mg once daily for 12 wks; 50–59 kg — 55 mg once daily for 12 wks; 45–49 kg — 45 mg once daily for 12 wks.IV Administration:
(Generic available)
(blood levels)
| ROUTE | ONSET | PEAK | DURATION |
| PO | rapid | 2–3 hr | 6–12 hr |
| PO — ER | unknown | 3.5–4 hr | 24 hr |
| IV | unknown | unknown | unknown |
NDC Code*