byoo-SUL-fan 
Absorption: Rapidly absorbed from the GI tract.
Distribution: Unknown.
Metabolism/Excretion: Extensively metabolized by the liver.
Half-life: 2.5 hr.
Contraindicated in:
Use Cautiously in:
Incidence and severity of adverse reactions and side effects are increased with IV use
CV: PO: CARDIAC TAMPONADE (WITH HIGH-DOSE CYCLOPHOSPHAMIDE).
IV: chest pain, hypotension, tachycardia, thrombosis, arrhythmias, atrial fibrillation, cardiomegaly, ECG changes, edema, heart block, heart failure, hypertension, pericardial effusion, ventricular extrasystoles.
Derm: PO: itching, rash, acne, alopecia, erythema nodosum, exfoliative dermatitis, hyperpigmentation.
EENT: PO: cataracts.
IV: epistaxis, pharyngitis, ear disorders.
Endo: PO and IV: hyperuricemia.
IV: hyperglycemia.
PO: sterility, gynecomastia.
F and E: hypokalemia, hypomagnesemia, hypophosphatemia.
GI: PO: drug-induced hepatitis, nausea, vomiting.
IV: abdominal enlargement, anorexia, constipation, diarrhea, dry mouth, hematemesis, nausea, rectal discomfort, vomiting, abdominal pain, dyspepsia, hepatic veno-occlusive disease (↑ in allogenic transplantation), hepatomegaly, pancreatitis, stomatitis.
GU: oliguria, dysuria, hematuria, ↓ fertility.
Hemat: BONE MARROW DEPRESSION.
Local: inflammation/pain at injection site.
MS: arthralgia, myalgia, back pain.
Neuro: IV: SEIZURES, CEREBRAL HEMORRHAGE/COMA, anxiety, confusion, depression, dizziness, headache, encephalopathy, mental status changes, weakness.
Resp: PO: PULMONARY FIBROSIS.
IV: alveolar hemorrhage, asthma, atelectasis, cough, hemoptysis, hypoxia, pleural effusion, pneumonia, rhinitis, sinusitis.
Misc: allergic reactions, chills, fever, infection.
Drug-Drug:
IV Administration:
0.5 mg/mL. When drawing busulfan from vial, use needle with 5-micron nylon filter provided, remove calculated volume from vial, remove needle and filter, replace needle and inject busulfan into diluent. Do not use polycarbonate syringes with busulfan. Only use filters provided with busulfan. Always add busulfan to diluent, not diluent to busulfan. Solution diluted with 0.9% NaCl or D5W is stable for 8 hr at room temperature and solution diluted with 0.9% NaCl is stable for 12 hr if refrigerated. Administration must be completed during this time. Solution is clear and colorless; do not administer solutions that are discolored or contain a precipitate.NDC Code*