section name header

Pronunciation ⬇

bay-ta-METH-a-sone audio

Indications ⬆ ⬇

REMS

Unlabeled Use:

Action ⬆ ⬇

Therapeutic Effects:

Pharmacokinetics ⬆ ⬇

Absorption: Sodium phosphate salt is rapidly absorbed after IM administration. Acetate salt is slowly but completely absorbed after IM administration. Absorption from local sites (intra-articular, intralesional) is slow but complete.

Distribution: Widely distributed; crosses the placenta and probably enters breast milk.

Metabolism/Excretion: Metabolized mostly by the liver.

Half-life: 3–5 hr (plasma), 36–54 hr (tissue); adrenal suppression lasts 3.25 days.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Adverse reactions/side effects are much more common with high-dose/long-term therapy

CV: hypertension.

Derm: acne, ↓wound healing, ecchymoses, fragility, hirsutism, petechiae.

EENT: cataracts, ↑ intraocular pressure.

Endo: adrenal suppression, hyperglycemia.

F and E: fluid retention (long-term high doses), hypokalemia, hypokalemic alkalosis.

GI: PEPTIC ULCERATION, anorexia, nausea, vomiting.

Hemat: THROMBOEMBOLISM, thrombophlebitis.

Metab: weight gain, weight loss.

MS: muscle wasting, osteoporosis, avascular necrosis of joints, muscle pain.

Neuro: depression, euphoria, headache, ↑ intracranial pressure (children only), personality changes, psychoses, restlessness.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), cushingoid appearance (moon face, buffalo hump), ↑ susceptibility to infection.

Interactions ⬆ ⬇

Drug-Drug:

Route/Dosage ⬆ ⬇

see Calculator

Implementation ⬆ ⬇

US Brand Names ⬆ ⬇

Celestone Soluspan

Canadian Brand Names ⬆ ⬇

Betaject

Classifications ⬆ ⬇

Therapeutic Classification: corticosteroids

Pharmacologic Classification: corticosteroids

Availability ⬆ ⬇

(Generic available)

Time/Action Profile ⬆ ⬇

(anti-inflammatory activity)

ROUTEONSETPEAKDURATION
IM (sodium phosphate/acetate)1–3 hrunknown1 wk

Assessment ⬆ ⬇

Lab Test Considerations:

Pot. Nursing Diagnoses ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

Code ⬆

NDC Code*