section name header

Pronunciation ⬇

mox-i-FLOX-a-sin audio

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

Therapeutic Effects:

Spectrum:

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (90%) following oral administration.

Distribution: Widely distributed; tissue concentrations may exceed plasma concentrations.

Metabolism/Excretion: Mostly metabolized by the liver; 20% excreted unchanged in urine, 25% excreted unchanged in feces.

Half-life: 12 hr.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: AORTIC ANEURYSM/DISSECTION, TORSADE DE POINTES, QT interval prolongation.

Derm: STEVENS-JOHNSON SYNDROME, photosensitivity.

Endo: hyperglycemia, hypoglycemia.

GI: CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, nausea, abdominal pain, dyspepsia, ↑ liver enzymes, vomiting.

MS: arthralgia, myalgia, tendinitis, tendon rupture.

Neuro: peripheral neuropathy , ELEVATED INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), SEIZURES, SUICIDAL THOUGHTS, agitation, anxiety, confusion, depression, dizziness, hallucinations, headache, insomnia, nightmares, paranoia, toxic psychosis, tremor.

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS).

Interactions ⬆ ⬇

Drug-Drug:

Route/Dosage ⬆ ⬇

Implementation ⬆ ⬇

US Brand Names ⬆ ⬇

Avelox

Classifications ⬆ ⬇

Therapeutic Classification: anti-infectives

Pharmacologic Classification: Fluoroquinolones

Availability ⬆ ⬇

(Generic available)

Time/Action Profile ⬆ ⬇

(blood levels)

ROUTEONSETPEAKDURATION
POwithin 1 hr1–3 hr24 hr
IVrapidend of infusion24 hr

Assessment ⬆ ⬇

Lab Test Considerations:

Pot. Nursing Diagnoses ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

Code ⬆

NDC Code*