mon-te-LOO-kast 
Absorption: Rapidly absorbed (63–73%) following oral administration.
Distribution: Unknown.
Protein Binding: 99%.
Metabolism/Excretion: Mostly metabolized by the liver by the CYP3A4 and CYP2C9 isoenzymes; metabolites eliminated in feces via bile; negligible renal excretion.
Half-life: 2.7–5.5 hr.
Contraindicated in:
Use Cautiously in:
Derm: STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, rash.
EENT: nosebleed, otitis (children), sinusitis (children).
GI: abdominal pain, diarrhea (children), dyspepsia, nausea (children), ↑ liver enzymes.
Neuro: SUICIDAL BEHAVIORS/THOUGHTS, agitation, aggression, anxiety, attention disturbance, depression, disorientation, dream abnormalities, fatigue, hallucinations, headache, insomnia, irritability, memory impairment, obsessive-compulsive symptoms, restlessness, sleep walking, stuttering, weakness., tics, tremor.
Resp: cough, rhinorrhea.
Misc: EOSINOPHILIC CONDITIONS (INCLUDING CHURG-STRAUSS SYNDROME), fever.
Drug-Drug:
Asthma
15 yr): 10 mg once daily.Exercise-Induced Bronchoconstriction
15 yrs): 10 mg 2 hr before exercise. Do not take within 24 hr of another dose; if taking daily doses, do not take dose for EIB.2 hr before exercise. Do not take within 24 hr of another dose; if taking daily doses, do not take dose for EIB.Allergic Rhinitis
15 yr): Seasonal or perennial — 10 mg once daily.Therapeutic Classification: allergy, cold and cough remedies, bronchodilators
Pharmacologic Classification: leukotriene antagonists
(Generic available)
(improved symptoms of asthma)
| ROUTE | ONSET | PEAK† | DURATION |
|---|---|---|---|
| PO (swallow) | within 24 hr | 3–4 hr | 24 hr |
| PO (chew) | within 24 hr | 2–2.5 hr | 24 hr |
NDC Code*
