section name header

Pronunciation

sil-OS-tah-zol audio

Indications

REMS

Action

Therapeutic Effects:

Pharmacokinetics

Absorption: Slowly absorbed after oral administration.

Distribution: Unknown.

Protein Binding: 95–98% bound to plasma proteins; one active metabolite is 97.4% bound, the other is 66% bound.

Metabolism/Excretion: Extensively metabolized by the liver, two metabolites have platelet aggregation inhibitory activity; metabolites are mostly excreted by the kidneys.

Half-life: Cilostazol and its active metabolites — 11–13 hr.

Contraind./Precautions

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects

CV: hypotension, left ventricular outflow obstruction, palpitations, tachycardia.

GI: diarrhea.

Neuro: headache, dizziness.

Interactions

Drug-Drug:

Drug-Food:

Route/Dosage

Implementation

US Brand Names

Pletal

Classifications

Therapeutic Classification: antiplatelet agents

Pharmacologic Classification: platelet aggregation inhibitors

Availability

(Generic available)

Time/Action Profile

(symptom reduction)

ROUTEONSETPEAKDURATION
PO2–4 wkup to 12 wkunknown

Assessment

Lab Test Considerations:

Pot. Nursing Diagnoses

Patient/Family Teaching

Evaluation/Desired Outcomes

Code

NDC Code*