Unlabeled Use:
Absorption: Appears to be well absorbed after oral administration.
Distribution: Extensively distributed throughout body tissues.
Protein Binding: 98%.
Metabolism/Excretion: Extensively metabolized by the liver; 1 metabolite has some antidepressant activity; 14% excreted unchanged in feces.
Half-life: 24 hr.
Contraindicated in:
Use Cautiously in:
CV: TORSADES DE POINTES, chest pain, palpitations, QT interval prolongation.
Derm: ↑sweating, hot flashes, rash.
EENT: pharyngitis, rhinitis, tinnitus, visual abnormalities.
Endo: diabetes.
F and E: hyponatremia.
GI: diarrhea, dry mouth, nausea, abdominal pain, altered taste, anorexia, constipation, dyspepsia, flatulence, ↑ appetite, vomiting.
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction, menstrual disorders, urinary disorders, urinary frequency.
MS: back pain, myalgia.
Neuro: tremor, hypertonia, hypoesthesia, paresthesia, twitching, SUICIDAL THOUGHTS, dizziness, drowsiness, fatigue, headache, insomnia, agitation, anxiety, confusion, emotional lability, impaired concentration, manic reaction, nervousness, weakness, yawning.
Misc: SEROTONIN SYNDROME, fever, ↑ thirst.
Drug-Drug:
Drug-Natural Products:
Depression/OCD
Panic Disorder
PTSD
Social Anxiety Disorder
PMDD
Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
NDC Code*