sil-DEN-a-fil 
Absorption: Rapidly absorbed (41%) after oral administration; IV administration results in complete bioavailability.
Distribution: Widely distributed to tissues; negligible amount in semen.
Protein Binding: 96%.
Metabolism/Excretion: Mostly metabolized by the liver (by P450 3A4 enzyme system); 1 metabolite is active and accounts for 20% or more of drug effect. Metabolites excreted mostly (80%) in feces; 13% excreted in urine.
Half-life: 4 hr (for sildenafil and active metabolite).
Contraindicated in:
Use Cautiously in:
CV: MYOCARDIAL INFARCTION, SUDDEN DEATH, hypotension, vaso-occlusive crises.
Derm: flushing, rash.
EENT: epistaxis, hearing loss, nasal congestion, vision loss.
GI: dyspepsia, diarrhea.
GU: priapism, urinary tract infection.
MS: mylagia.
Neuro: paresthesias , headache, dizziness, insomnia.
Drug-Drug:
Viagra (for erectile dysfunction)
65 yr or with concurrent enzyme inhibitors): 25 mg taken 1 hr before sexual activity (range 25–100 mg taken 30 min–4 hr before sexual activity); not more than once daily.Hepatic Impairment
Revatio (for pulmonary arterial hypertension)
IV therapy is indicated for patients unable to take PO therapyIV Administration:
Therapeutic Classification: erectile dysfunction agents, vasodilators
Pharmacologic Classification: phosphodiesterase type 5 inhibitors
(Generic available)
NDC Code*
