TRAZ-oh-done 
Absorption: Well absorbed after oral administration.
Distribution: Widely distributed.
Protein Binding: 89–95%.
Metabolism/Excretion: Extensively metabolized by the liver (CYP3A4 enzyme system); minimal excretion of unchanged drug by the kidneys.
Half-life: 5–9 hr (immediate-release).
Contraindicated in:
Use Cautiously in:
EENT: blurred vision, tinnitus.
CV: hypotension, arrhythmias, chest pain, hypertension, palpitations, QT interval prolongation, tachycardia.
GI: dry mouth, altered taste, constipation, diarrhea, excess salivation, flatulence, nausea, vomiting.
GU: hematuria, erectile dysfunction, priapism, urinary frequency.
Derm: rash.
Hemat: anemia, leukopenia.
MS: myalgia.
Neuro: tremor , SUICIDAL THOUGHTS, drowsiness, confusion, dizziness, fatigue, hallucinations, headache, insomnia, nightmares, slurred speech, syncope, weakness.
Drug-Drug:
Drug-Natural Products:
Depression
Insomnia
24 yr. After starting therapy, children, adolescents, and young adults should be seen by health care professional at least weekly for 4 wk, every 3 wk for next 4 wk, and on advice of health care professional thereafter.NDC Code*
