ess-sit-AL-o-pram 
Unlabeled Use:
Absorption: 80% absorbed following oral administration.
Distribution: Enters breast milk.
Metabolism/Excretion: Mostly metabolized by the liver (primarily CYP3A4 and CYP2C19 isoenzymes); 7% excreted unchanged by kidneys.
Half-life: ↑in elderly and patients with hepatic impairment.
Contraindicated in:
Use Cautiously in:
Derm: sweating.
Endo: syndrome on inappropriate secretion of antidiuretic hormone (SIADH).
F and E: hyponatremia.
GI: diarrhea, nausea, abdominal pain, constipation, dry mouth, indigestion.
GU: ↓libido, delayed/absent orgasm, ejaculatory delay/failure, erectile dysfunction.
Metab: ↑appetite.
Neuro: NEUROLEPTIC MALIGNANT SYNDROME, SUICIDAL THOUGHTS, insomnia, dizziness, drowsiness, fatigue.
Misc: SEROTONIN SYNDROME.
Drug-Drug:
Drug-Natural Products:
Hepatic Impairment
12 yr): Depression — 10 mg once daily, may ↑ to 20 mg once daily after 3 wk.Therapeutic Classification: antidepressants
Pharmacologic Classification: selective serotonin reuptake inhibitors ssris
24 yr. After starting therapy, children, adolescents, and young adults should be seen by health care professional at least weekly for 4 wk, every 3 wk for next 4 wk, and on advice of health care professional thereafter.NDC Code*
