section name header

Pronunciation ⬇

ZOLE-pi-dem

Classifications ⬆ ⬇

Therapeutic Classification: sedative/hypnotics

Indications ⬆ ⬇

BEERS REMS

Action ⬆ ⬇

  • Produces CNS depression by binding to GABA receptors.
  • Has no analgesic properties.
Therapeutic effects:
  • Sedation and induction of sleep.

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed following oral administration. Controlled-release formulation releases 10 mg immediately, then another 2.5 mg later.

Distribution: Unknown.

Metabolism/Excretion: Converted to inactive metabolites, which are excreted by the kidneys; clearance of sublingual tablet lower in women than in men.

Half-Life: 2.5–3 hr (↑ in older adults and patients with hepatic impairment).

Time/Action Profile ⬆ ⬇

(sedation)

ROUTEONSETPEAK*DURATION
POrapid30 min–2 hr6–8 hr
PO-ERrapid2–4 hr6–8 hr
SLrapidunknownunknown



*Food delays peak levels and effects.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

EENT: blurred vision, double vision

GI: diarrhea, nausea, vomiting

Neuro: daytime drowsiness, dizziness, abnormal thinking, agitation, amnesia, behavior changes, COMPLEX SLEEP BEHAVIORS (INCLUDING SLEEP DRIVING, SLEEP WALKING, OR ENGAGING IN OTHER ACTIVITIES WHILE SLEEPING), delirium, hallucinations, prolonged reaction time

Resp: respiratory depression

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), physical dependence, psychological dependence, tolerance

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Ambien, Ambien CR, Edluar

Canadian Brand Names ⬆ ⬇

Sublinox

Contr. Subst. Schedule ⬆ ⬇

Schedule IV (C-IV)

Pill Image

zolpidemtartrate_195-8664.jpg

Code ⬆

NDC Code