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Pronunciation ⬇

PRED-ni-sone

Classifications ⬆ ⬇

Therapeutic Classification: corticosteroids (intermediate acting), immune modifiers

Pharmacologic Classification: corticosteroids

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • In pharmacologic doses, suppresses inflammation and the normal immune response.
  • Suppresses adrenal function at chronic doses of 5 mg/day.
  • Replaces endogenous cortisol in deficiency states.
  • Has minimal mineralocorticoid activity.
Therapeutic effects:
  • Suppression of inflammation and modification of the normal immune response.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral administration.

Distribution: Widely distributed.

Metabolism/Excretion: Converted by the liver to prednisolone, which is then metabolized by the liver.

Half-Life: 3.4–3.8 hr (plasma), 18–36 hr (tissue); adrenal suppression lasts 1.25–1.5 days.

Time/Action Profile ⬆ ⬇

(anti-inflammatory activity)

ROUTEONSETPEAKDURATION
POhrsunknown1.25–1.5 days



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Adverse reactions/side effects are much more common with high-dose/long-term therapy

CV: hypertension

Derm: acne, ↓wound healing, ecchymoses, hirsutism, petechiae

EENT: cataracts, ↑intraocular pressure

Endo: adrenal suppression, cushingoid appearance (moon face, buffalo hump), hyperglycemia

F and E: fluid retention (long-term high doses), hypokalemia, hypokalemic alkalosis

GI: anorexia, nausea, PEPTIC ULCERATION, vomiting

Hemat: THROMBOEMBOLISM, thrombophlebitis

Metab: weight gain, weight loss

MS: muscle wasting, osteoporosis, avascular necrosis of joints, muscle pain

Neuro: depression, euphoria, headache, ↑intracranial pressure (children only), personality changes, psychoses, restlessness

Misc: INFECTION, KAPOSI'S SARCOMA

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Rayos

Canadian Brand Names ⬆ ⬇

Winipred

Pill Image

prednisone_195-1223.jpg

Code ⬆

NDC Code