a-mox-i-SILL-in
Therapeutic Classification: anti-infectives, antiulcer agents
Pharmacologic Classification: aminopenicillins
REMS
Spectrum:
Absorption: Well absorbed from duodenum (75–90%). More resistant to acid inactivation than other penicillins.
Distribution: Diffuses readily into most body tissues and fluids. CSF penetration increased when meninges are inflamed. Crosses placenta; enters breast milk in small amounts.
Half-Life: Neonates: 3.7 hr; Infants and Children: 1–2 hr; Adults: 0.7–1.4 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria
GI: diarrhea, ↑liver enzymes, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), nausea, vomiting
Hemat: blood dyscrasias
Neuro: SEIZURES (HIGH DOSES)
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS), SERUM SICKNESS, superinfection
Drug-drug:
Most Infections
Renal Impairment
Helicobacter pylori
Endocarditis Prophylaxis
Lab Test Considerations:
H. pylori
with resolution of ulcer symptoms.NDC Code
