section name header

Pronunciation ⬇

byoo-MET-a-nide

Classifications ⬆ ⬇

Therapeutic Classification: diuretics

Pharmacologic Classification: loop diuretics

Indications ⬆ ⬇

BEERS REMS

Unlabeled Use:
  • Reversal of oliguria in preterm neonates.

Action ⬆ ⬇

  • Inhibits the reabsorption of sodium and chloride from the loop of Henle and distal renal tubule.
  • Increases renal excretion of water, sodium chloride, magnesium, potassium, and calcium.
  • Effectiveness persists in impaired renal function.
Therapeutic effects:
  • Diuresis and subsequent mobilization of excess fluid (edema, pleural effusions).

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed after oral or IM administration. IV administration results in complete bioavailability.

Distribution: Widely distributed.

Protein Binding: 72–96%.

Metabolism/Excretion: Partially metabolized by liver; 50% eliminated unchanged by kidneys and 20% excreted in feces.

Half-Life: 60–90 min (6 hr in neonates).

Time/Action Profile ⬆ ⬇

(diuretic effect)

ROUTEONSETPEAKDURATION
PO30–60 min1–2 hr4–6 hr
IM30–60 min1–2 hr4–6 hr
IV2–3 min15–45 min2–3 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: hypotension

Derm: photosensitivity, pruritus, rash, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS

EENT: hearing loss, tinnitus

Endo: hyperglycemia, hyperuricemia

F and E: dehydration, hypochloremia, hypokalemia, hypomagnesemia, hyponatremia, hypovolemia, metabolic alkalosis, hypocalcemia

GI: diarrhea, dry mouth, nausea, vomiting

GU: ↑BUN

MS: arthralgia, muscle cramps, myalgia

Neuro: dizziness, encephalopathy, headache

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

IV Administration:

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Bumex

Canadian Brand Names ⬆ ⬇

Burinex

Code ⬆

NDC Code