nye-tro-GLI-ser-in
REMS
Absorption: Well absorbed after oral, buccal, and sublingual administration. Also absorbed through skin. Orally administered nitroglycerin is rapidly metabolized, leading to ↓ bioavailability.
Distribution: Unknown.
Half-Life: 1–4 min.
(cardiovascular effects)
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| SL/Translingual | 1–3 min | unknown | 30–60 min |
| PO-ER | 40–60 min | unknown | 8–12 hr |
| Oint | 20–60 min | unknown | 4–8 hr |
| Patch | 40–60 min | unknown | 8–24 hr |
| IV | immediate | unknown | several min |
Contraindicated in:
Use Cautiously in:
CV: hypotension, tachycardia, syncope
Derm: contact dermatitis (transdermal), flushing
EENT: blurred vision
GI: abdominal pain, nausea, vomiting
Neuro: dizziness, headache, apprehension, restlessness, weakness.
Misc: alcohol intoxication (large IV doses only), tolerance
Drug-drug:
Translingual Spray
(Adults ): 1–2 sprays; may be repeated every 5 min for 2 additional doses for acute attack; may also be used prophylactically 5–10 min before activities that may precipitate an acute attack.Lab Test Considerations:
IV Administration:
nitroglycerin extended-release capsules: Nitro-Time,
nitroglycerin intravenous: Nitro-Bid IV, Tridil,
nitroglycerin sublingual tablets: Nitrostat,
nitroglycerin transdermal ointment: Nitro-Bid,
nitroglycerin transdermal patch: Nitro-Dur,
nitroglycerin translingual spray: Nitrolingual, Nitromist
nitroglycerin intravenous: Nitroject,
nitroglycerin transdermal patch: Trinipatch,
nitroglycerin translingual spray: Rho-Nitro
NDC Code