section name header

Pronunciation ⬇

sye-kloe-BEN-za-preen

Classifications ⬆ ⬇

Therapeutic Classification: skeletal muscle relaxants (centrally acting)

Indications ⬆ ⬇

BEERS REMS

Unlabeled Use:

Action ⬆ ⬇

  • Reduces tonic somatic muscle activity at the level of the brain stem. Structurally similar to tricyclic antidepressants.
Therapeutic effects:
  • Reduction in muscle spasm and hyperactivity without loss of function.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed from the GI tract.

Distribution: Unknown.

Protein Binding: 93%.

Metabolism/Excretion: Mostly metabolized by the liver.

Half-Life: 1–3 days.

Time/Action Profile ⬆ ⬇

(skeletal muscle relaxation)

ROUTEONSETPEAK‡DURATION
POwithin 1 hr3–8 hr12–24 hr
Extended releaseunknownunknown24 hr



‡Full effects may not occur for 1–2 wk.

Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmias

EENT: dry mouth, blurred vision

GI: constipation, dyspepsia, nausea, unpleasant taste

GU: urinary retention

Neuro: dizziness, drowsiness, confusion, fatigue, headache, nervousness

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Amrix, Fexmid, Flexeril

Code ⬆

NDC Code