• For chemotherapy, aprepitant is given as part of a regimen that includes a corticosteroid and a 5-HT₃ antagonist (see Route/Dosage).
• PO: Administer daily for 3 days. Day 1: administer 1 hr prior to chemotherapy. Days 2 and 3: administer once in the morning. May be administered without regard to food. DNC: Swallow capsules whole; do not open, crush, or chew.
  • Oral suspension may be used for pediatric patients or those with difficulty swallowing. Follow manufacture's instructions for preparing suspension. Refrigerate suspension; may be stored at room temperature for up to 3 hrs before use. To administer, take cap off, place dispenser in patient's mouth along inner cheek. Dispense slowly. Discard after 72 hrs.

IV Administration:

Cinvanti

• Complete injection or infusion 30 min prior to chemotherapy.

• Withdraw 18 mL for the 130 mg dose or 14 mL for the 100 mg dose from the vial. Do not dilute.

• Rate: Inject over 2 min. Flush line with 0.9% NaCl before and after injection.
• Intermittent Infusion: Diluent: 0.9% NaCl or D5W.For Highly-Emetogenic Chemotherapy: Using 130 mL of diluent, withdraw 18 mg aprepitant from vial and add to bag for 148 mL. For Moderately-Emetogenic Chemotherapy: Using 100 mL of diluent, withdraw 14 mL aprepitant from vial and add to bag for 114 mL. Mix by gently inverting bag 4–5 times. Solution is an opaque, off-white emulsion. Do not administer solutions that are discolored or contain particulate matter. May be stored at room temperature for 6 hrs if mixed with 0.9% NaCl or 12 hrs if mixed with D5W or in refrigerator for up to 72 hrs.
• Rate: Infuse over 30 min.

Emend

• Complete injection or infusion 30 min prior to chemotherapy.
• Intermittent Infusion: Reconstitution: Inject 5 mL of 0.9% NaCl into vial along the vial wall to prevent foaming. Swirl vial gently. Avoid shaking and jetting 0.9% NaCl into the vial.Diluent: Withdraw entire volume from vial and transfer to infusion bag containing 145 mL of 0.9% NaCl for a volume of 150 mL.Final concentration of 1 mg/mL.Gently invert bag 2 to 3 times. Solution is stable for 24 hrs at room temperature. Discard unused portion.
• Rate: Infuse over 20–30 min for adults, over 30 min for children 12–17 yrs, or over 60 min for children 6 mos to <12 yrs. For children may also be given as a 3–day regimen via central venous catheter. For children 12–17 yrs, Day 1: infuse 115 mg over 30 min; Day 2 and 3: infuse 80 mg over 30 min. For children 6 mos to <12 yrs, Day 1: infuse 3 mg/kg up to 115 mg over 60 min; Day 2 and 3: infuse 2 mg/kg up to 80 mg over 60 min.

Aponvie

• Withdraw 4.4 mL from vial. Solution is opaque and off-white to amber. Do not administer solutions that are discolored or contain particulate matter. Flush the infusion line with 0.9% NaCl before and after administration.

• Rate: Administer over 30 sec prior to induction of anesthesia.