le-voe-FLOX-a-sin
REMS
Spectrum:
Absorption: Well absorbed (99%) after oral administration; IV administration results in complete bioavailability.
Distribution: Widely distributed. High tissue and urinary levels are achieved. Appears to cross the placenta.
Protein Binding: 24–38%
Half-Life: 8 hr.
Contraindicated in:
Use Cautiously in:
CV: AORTIC ANEURYSM/DISSECTION, myocardial ischemia, QT interval prolongation, TORSADES DE POINTES
Derm: acute generalized exanthematous pustulosis, photosensitivity, rash, STEVENS-JOHNSON SYNDROME
Endo: hyperglycemia, hypoglycemia
GI: nausea, abdominal pain, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), diarrhea, HEPATOTOXICITY, vomiting
GU: vaginitis
Local: phlebitis at IV site
MS: arthralgia, myalgia, tendinitis, tendon rupture
Neuro: ↑INTRACRANIAL PRESSURE (INCLUDING PSEUDOTUMOR CEREBRI), agitation, anxiety, confusion, depression, dizziness, hallucinations, headache, insomnia, light-headedness, nightmares, paranoia, peripheral neuropathy, SEIZURES, SUICIDAL THOUGHTS/BEHAVIORS, toxic psychosis, tremor
Drug-drug:
Nosocomial Pneumonia
Community-Acquired Pneumonia
Skin/Skin Structure Infections
Chronic Bacterial Prostatitis
Inhalational Anthrax (Postexposure)
Plague
Urinary Tract Infections
Acute Bacterial Exacerbations of Chronic Bronchitis
Acute Sinusitis
Renal Impairment
Clostridioides difficile
occurs, treat as clinically indicated. May begin up to several wk following cessation of therapy.Lab Test Considerations:
Intermittent Infusion:
Rate: Infuse 250-mg or 500-mg doses over 60 min and 750-mg dose over 90 min. Avoid rapid bolus injection to prevent hypotension.
Y-Site Incompatibility:
IV Administration:
NDC Code
