section name header

Pronunciation ⬇

lor-A-ta-deen

Classifications ⬆ ⬇

Therapeutic Classification: allergy, cold and cough remedies

Pharmacologic Classification: antihistamines

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Blocks peripheral effects of histamine released during allergic reactions.
Therapeutic effects:
  • Decreased symptoms of allergic reactions (nasal stuffiness; red, swollen eyes, itching).

Pharmacokinetics ⬆ ⬇

Absorption: Rapidly absorbed after oral administration (80%).

Distribution: Unknown.

Protein Binding: Loratadine: 97%; descarboethoxyloratadine: 73–77%.

Metabolism/Excretion: Rapidly and extensively metabolized during first pass through the liver. Much is converted to descarboethoxyloratadine, an active metabolite.

Half-Life: Loratadine: 8.4 hr; descarboethoxyloratadine: 28 hr.

Time/Action Profile ⬆ ⬇

(antihistaminic effects)

ROUTEONSETPEAKDURATION
PO1–3 hr8–12 hr>24 hr



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

Derm: photosensitivity, rash

EENT: blurred vision

GI: dry mouth, GI upset

Metab: weight gain

Neuro: confusion, drowsiness (rare), paradoxical excitation

Interactions ⬆ ⬇

Drug-drug:

Drug-Natural Products:

Route/Dosage ⬆ ⬇

Renal Impairment

Hepatic Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Alavert, Claritin, Claritin Allergy Childrens, Claritin Childrens, Claritin Reditabs, Loradamed

Code ⬆

NDC Code