Therapeutic Classification: anti-infectives
Pharmacologic Classification: aminopenicillins beta lactamase inhibitors
REMS
Spectrum:
Absorption: Well absorbed from IM sites.
Distribution: Ampicillin diffuses readily into bile, blister and tissue fluids. Poor CSF penetration unless meninges are inflamed.
Protein Binding: Ampicillin: 28%; sulbactam: 38%.
Half-Life: Ampicillin: 1–1.8 hr; sulbactam: 1–1.3 hr.
Contraindicated in:
Use Cautiously in:
Derm: rash, ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria
GI: diarrhea, cholestasis, CLOSTRIDIOIDES DIFFICILE-ASSOCIATED DIARRHEA (CDAD), HEPATOTOXICITY, nausea, vomiting
Hemat: blood dyscrasias
Local: pain at injection site, phlebitis
Neuro: SEIZURES (HIGH DOSES)
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND MYOCARDIAL ISCHEMIA [WITH OR WITHOUT MI]), superinfection
Drug-drug:
Renal Impairment
Lab Test Considerations:
IV Administration:
NDC Code