IV Administration:

• Solution should be prepared in a biologic cabinet. Wear gloves, gown, and mask while handling IV medication. Discard IV equipment in specially designated containers.
  • Solution is slightly yellow. Do not administer solutions that are discolored or contain particulate matter. Reconstituted solution and diluted solution are stable in an IV bag for 6 hr at room temperature or if refrigerated. Discard unused solutions.
• Extravasation Protection: Administer as soon as possible within 6 hr of extravasation in a large caliber vein in an extremity/area other than the one affected by the extravasation. Remove cooling procedures, such as ice packs, at least 15 min before administration to allow sufficient blood flow to area of extravasation. Start treatment on Day 2 and Day 3 at same hr (+/- 3 hr) as on first day.
• : Intermittent Infusion: Reconstitution: Reconstitute with 50 mL sterile water for injection.Concentration: 10 mg/mLDiluent: Withdraw dose volume within 30 min of reconstitution and inject into 1000 mL bag of LR. Solution is stable for 4 hr at room temperature or 12 hr if refrigerated.
• Rate: Infuse over 1–2 hr in a large caliber vein.
• Cardioprotective: Doxorubicin should be administered within 30 min following dexrazoxane administration.
• : Intermittent Infusion: Reconstitution: Reconstitute with 25 mL sterile water for injection for 250-mg vial or 50 mL for 500-mg vial.Concentration: 10 mg/mL.Diluent: Dilute reconstituted solution further in LR1.3–5 mg/mL. Solution is stable for 1 hr at room temperature or 4 hr if refrigerated.
• Rate: Infuse over 15 min. Administer doxorubicin within 30 min of completion of infusion. Do not administer via IV push.