section name header

Pronunciation ⬇

fen-o-FI-brate

Classifications ⬆ ⬇

Therapeutic Classification: lipid-lowering agents

Pharmacologic Classification: fibric acid derivatives

Indications ⬆ ⬇

REMS

Action ⬆ ⬇

  • Fenofibric acid primarily inhibits triglyceride synthesis.
Therapeutic effects:
  • Lowering of cholesterol and triglycerides with subsequent decreased risk of pancreatitis.

Pharmacokinetics ⬆ ⬇

Absorption: Well absorbed (60%) after oral administration; absorption ↑ by food.

Distribution: Unknown.

Protein Binding: 99%.

Metabolism/Excretion: Rapidly converted to fenofibric acid, which is the active metabolite; fenofibric acid is metabolized by the liver. Fenofibric acid and its metabolites are primarily excreted in urine (60%).

Half-Life: 20 hr.

Time/Action Profile ⬆ ⬇

(lowering of triglycerides)

ROUTEONSETPEAKDURATION
POunknown2 wkunknown



Contraind./Precautions ⬆ ⬇

Contraindicated in:

Use Cautiously in:

Adv. Reactions/Side Effects ⬆ ⬇

CV: arrhythmia, DEEP VEIN THROMBOSIS

Derm: rash, DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS), STEVENS-JOHNSON SYNDROME, TOXIC EPIDERMAL NECROLYSIS, urticaria

GI: ↑liver enzymes, cholelithiasis, HEPATOTOXICITY, pancreatitis

Metab: ↓HDL levels

MS: rhabdomyolysis

Neuro: fatigue/weakness, headache

Resp: INTERSTITIAL LUNG DISEASE, PULMONARY EMBOLISM

Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)

Interactions ⬆ ⬇

Drug-drug:

Route/Dosage ⬆ ⬇

Primary Hypercholesterolemia/Mixed Dyslipidemia

Renal Impairment

Hypertriglyceridemia

Renal Impairment

Availability ⬆ ⬇

(Generic available)

Assessment ⬆ ⬇

Lab Test Considerations:

Implementation ⬆ ⬇

Patient/Family Teaching ⬆ ⬇

Evaluation/Desired Outcomes ⬆ ⬇

US Brand Names ⬆ ⬇

Antara, Fenoglide, Lipofen, Tricor, Triglide

Canadian Brand Names ⬆ ⬇

Lipidil EZ, Lipidil Supra

Pill Image

fenofibrate_195-8975.jpg

Code ⬆

NDC Code