Therapeutic Classification: antipsychotics, mood stabilizers
Pharmacologic Classification: benzisoxazoles
BEERS REMS
Absorption: 70% after administration of tablets, solution, or orally disintegrating tablets. Following IM administration, small initial release of drug, followed by 3-wk lag; the rest of release starts at 3 wk and lasts 46 wk. Following SUBQ administration, initial release of drug occurs at 46 hr, with the rest of release occurring at 1014 days after administration.
Distribution: Unknown.
Half-Life: Extensive metabolizers: 3 hr for risperidone, 21 hr for 9-hydroxyrisperidone. Poor metabolizers: 20 hr for risperidone and 30 hr for 9-hydroxyrisperidone; SUBQ: 911 days.
(clinical effects)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | 12 wk | unknown | up to 6 wk‡ |
IM | 3 wk | 46 wk | up to 6 wk‡ |
SUBQ | 2 wk | 68 wk | unknown |
‡After discontinuation.
Contraindicated in:
Use Cautiously in:
CV: arrhythmias, orthostatic hypotension, syncope, tachycardia
Derm: itching/skin rash, ↑pigmentation, dry skin, photosensitivity, seborrhea, STEVENS-JOHNSON SYNDROME, sweating, TOXIC EPIDERMAL NECROLYSIS
EENT: pharyngitis, rhinitis, visual disturbances
Endo: galactorrhea, hyperglycemia
F and E: polydipsia
GI: constipation, diarrhea, dry mouth, nausea, ↑salivation, abdominal pain, anorexia, dyspepsia, dysphagia, vomiting
GU: ↓libido, dysmenorrhea/menorrhagia, ↓fertility (females), amenorrhea, difficulty urinating, gynecomastia, impotence, polyuria, priapism
Hemat: AGRANULOCYTOSIS, leukopenia, neutropenia
MS: arthralgia, back pain
Neuro: ↑dreams, ↑sleep duration, aggressive behavior, dizziness, extrapyramidal reactions, headache, insomnia, sedation, fatigue, impaired temperature regulation, nervousness, NEUROLEPTIC MALIGNANT SYNDROME, SEIZURES, tardive dyskinesia
Misc: HYPERSENSITIVITY REACTIONS (INCLUDING ANAPHYLAXIS AND ANGIOEDEMA)
Drug-drug:
Drug-Natural Products:
Schizophrenia
Acute Manic or Mixed Episodes Associated With Bipolar I Disorder
Maintenance Treatment of Bipolar I Disorder
Irritability Associated With Autistic Disorder
Lab Test Considerations:
NDC Code