per-FEN-a-zeen
Therapeutic Classification: antiemetics, antipsychotics (conventional)
Pharmacologic Classification: phenothiazines
Absorption: 20% absorbed following oral administration.
Distribution: Widely distributed, high concentrations in the CNS.
Protein Binding: ≥90%.
Half-Life: 8.4–12.3 hr.
| ROUTE | ONSET | PEAK | DURATION |
|---|---|---|---|
| PO | 2–6 hr | unknown | 6–12 hr |
‡Optimal antipsychotic response may not occur for several wk.
Contraindicated in:
Use Cautiously in:
CV: hypotension, tachycardia
Derm: photosensitivity, pigment changes, rash
EENT: blurred vision, dry eyes, lens opacities
Endo: galactorrhea, amenorrhea
GI: constipation, dry mouth, anorexia, ileus
GU: urinary retention, urine discoloration
Hemat: AGRANULOCYTOSIS, leukopenia
Neuro: extrapyramidal reactions, NEUROLEPTIC MALIGNANT SYNDROME, sedation, tardive dyskinesia
Misc: allergic reactions
Drug-drug:
Drug-Natural Products:
Schizophrenia
Lab Test Considerations:
NDC Code